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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m6l 21V Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m6l 21VDihydrofolate reductase 1.5.1.3 1.094
4keb FOLDihydrofolate reductase 1.5.1.3 0.790
4kfj FOLDihydrofolate reductase 1.5.1.3 0.786
2w3m FOLDihydrofolate reductase 1.5.1.3 0.783
3ghw GHWDihydrofolate reductase 1.5.1.3 0.765
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.763
4m6k FOLDihydrofolate reductase 1.5.1.3 0.762
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.760
1dhf FOLDihydrofolate reductase 1.5.1.3 0.755
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.754
2d0k FOLDihydrofolate reductase 1.5.1.3 0.753
2dhf DZFDihydrofolate reductase 1.5.1.3 0.749
4x5g FOLDihydrofolate reductase 1.5.1.3 0.747
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.745
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.745
4x5f FOLDihydrofolate reductase 1.5.1.3 0.744
1dyh DZFDihydrofolate reductase 1.5.1.3 0.742
1hfq MOTDihydrofolate reductase 1.5.1.3 0.740
3eig MTXDihydrofolate reductase 1.5.1.3 0.737
1dyi FOLDihydrofolate reductase 1.5.1.3 0.733
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.731
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.729
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.727
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.725
4x5i FOLDihydrofolate reductase 1.5.1.3 0.725
1ohk COPDihydrofolate reductase 1.5.1.3 0.724
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.722
3ghv GHCDihydrofolate reductase 1.5.1.3 0.722
1u70 MTXDihydrofolate reductase 1.5.1.3 0.721
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.720
1hfr MOTDihydrofolate reductase 1.5.1.3 0.719
4x5h FOLDihydrofolate reductase 1.5.1.3 0.718
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.717
4p66 MTXDihydrofolate reductase / 0.713
1hfp MOTDihydrofolate reductase 1.5.1.3 0.712
1drf FOLDihydrofolate reductase 1.5.1.3 0.711
3tq9 MTXDihydrofolate reductase / 0.711
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.708
4i13 FOLDihydrofolate reductase 1.5.1.3 0.708
4i1n FOLDihydrofolate reductase 1.5.1.3 0.706
3tqb FOLDihydrofolate reductase / 0.705
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.704
7dfr FOLDihydrofolate reductase 1.5.1.3 0.704
2zza FOLDihydrofolate reductase / 0.700
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.700
3och 2MXDihydrofolate reductase 1.5.1.3 0.697
3drc MTXDihydrofolate reductase 1.5.1.3 0.695
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.695
1drb MTXDihydrofolate reductase 1.5.1.3 0.694
1df7 MTXDihydrofolate reductase 1.5.1.3 0.693
1dhi MTXDihydrofolate reductase 1.5.1.3 0.692
2drc MTXDihydrofolate reductase 1.5.1.3 0.692
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.692
5ccc DDFDihydrofolate reductase 1.5.1.3 0.691
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.687
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.687
3dau MTXDihydrofolate reductase 1.5.1.3 0.687
3ia4 MTXDihydrofolate reductase / 0.686
4qi9 MTXDihydrofolate reductase / 0.686
5hi6 MTXDihydrofolate reductase / 0.686
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.685
2w3a TOPDihydrofolate reductase 1.5.1.3 0.684
1dra MTXDihydrofolate reductase 1.5.1.3 0.678
1dhj MTXDihydrofolate reductase 1.5.1.3 0.677
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.677
1e26 GPBDihydrofolate reductase 1.5.1.3 0.676
4p68 MTXDihydrofolate reductase / 0.676
1ohj COPDihydrofolate reductase 1.5.1.3 0.675
4fhb FOLDihydrofolate reductase 1.5.1.3 0.675
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.674
1u72 MTXDihydrofolate reductase 1.5.1.3 0.673
3nxo D2BDihydrofolate reductase 1.5.1.3 0.673
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.672
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.671
1dls MTXDihydrofolate reductase 1.5.1.3 0.670
4dfr MTXDihydrofolate reductase 1.5.1.3 0.669
1jom FFODihydrofolate reductase 1.5.1.3 0.667
2prh 238Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.667
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.666
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.663
4kjj FOLDihydrofolate reductase 1.5.1.3 0.660
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.657
1r4l XX5Angiotensin-converting enzyme 2 3.4.17.23 0.656
1dyj DDFDihydrofolate reductase 1.5.1.3 0.655
3dfr MTXDihydrofolate reductase 1.5.1.3 0.654
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.650
2g1m 4HGEgl nine homolog 1 / 0.650