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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m6k FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m6k FOLDihydrofolate reductase 1.5.1.3 1.046
4keb FOLDihydrofolate reductase 1.5.1.3 1.000
2w3m FOLDihydrofolate reductase 1.5.1.3 0.955
4kfj FOLDihydrofolate reductase 1.5.1.3 0.949
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.894
1dhf FOLDihydrofolate reductase 1.5.1.3 0.884
3ghw GHWDihydrofolate reductase 1.5.1.3 0.867
1hfq MOTDihydrofolate reductase 1.5.1.3 0.865
1hfr MOTDihydrofolate reductase 1.5.1.3 0.863
4x5g FOLDihydrofolate reductase 1.5.1.3 0.855
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.854
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.852
1hfp MOTDihydrofolate reductase 1.5.1.3 0.851
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.847
4x5f FOLDihydrofolate reductase 1.5.1.3 0.845
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.844
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.842
4i1n FOLDihydrofolate reductase 1.5.1.3 0.836
4kjj FOLDihydrofolate reductase 1.5.1.3 0.835
7dfr FOLDihydrofolate reductase 1.5.1.3 0.832
1dyh DZFDihydrofolate reductase 1.5.1.3 0.830
1drf FOLDihydrofolate reductase 1.5.1.3 0.829
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.829
2zza FOLDihydrofolate reductase / 0.819
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.814
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.811
4i13 FOLDihydrofolate reductase 1.5.1.3 0.811
3tqb FOLDihydrofolate reductase / 0.810
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.808
1dls MTXDihydrofolate reductase 1.5.1.3 0.807
4x5h FOLDihydrofolate reductase 1.5.1.3 0.807
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.805
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.800
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.800
3eig MTXDihydrofolate reductase 1.5.1.3 0.799
3ghv GHCDihydrofolate reductase 1.5.1.3 0.796
1u70 MTXDihydrofolate reductase 1.5.1.3 0.795
1dyi FOLDihydrofolate reductase 1.5.1.3 0.794
3dau MTXDihydrofolate reductase 1.5.1.3 0.793
4fhb FOLDihydrofolate reductase 1.5.1.3 0.791
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.790
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.788
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.787
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.785
2dhf DZFDihydrofolate reductase 1.5.1.3 0.782
3tq9 MTXDihydrofolate reductase / 0.779
1u72 MTXDihydrofolate reductase 1.5.1.3 0.778
1dre MTXDihydrofolate reductase 1.5.1.3 0.776
1dyj DDFDihydrofolate reductase 1.5.1.3 0.773
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.773
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.771
4dfr MTXDihydrofolate reductase 1.5.1.3 0.766
4m6l 21VDihydrofolate reductase 1.5.1.3 0.762
5ccc DDFDihydrofolate reductase 1.5.1.3 0.760
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.758
2qk8 MTXDihydrofolate reductase / 0.752
1ohj COPDihydrofolate reductase 1.5.1.3 0.751
4qi9 MTXDihydrofolate reductase / 0.747
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.745
1dra MTXDihydrofolate reductase 1.5.1.3 0.742
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.741
1tdr MTXDihydrofolate reductase 1.5.1.3 0.741
5hi6 MTXDihydrofolate reductase / 0.739
2d0k FOLDihydrofolate reductase 1.5.1.3 0.738
4x5i FOLDihydrofolate reductase 1.5.1.3 0.738
1e26 GPBDihydrofolate reductase 1.5.1.3 0.737
1df7 MTXDihydrofolate reductase 1.5.1.3 0.736
3dfr MTXDihydrofolate reductase 1.5.1.3 0.736
1ohk COPDihydrofolate reductase 1.5.1.3 0.733
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.732
1dhi MTXDihydrofolate reductase 1.5.1.3 0.730
3drc MTXDihydrofolate reductase 1.5.1.3 0.730
1drb MTXDihydrofolate reductase 1.5.1.3 0.727
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.721
2drc MTXDihydrofolate reductase 1.5.1.3 0.720
1jom FFODihydrofolate reductase 1.5.1.3 0.717
1dhj MTXDihydrofolate reductase 1.5.1.3 0.716
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.715
1re7 FOLDihydrofolate reductase 1.5.1.3 0.710
4p66 MTXDihydrofolate reductase / 0.707
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.705
3och 2MXDihydrofolate reductase 1.5.1.3 0.697
4p68 MTXDihydrofolate reductase / 0.696
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.688
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.687
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.683
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.679
3ia4 MTXDihydrofolate reductase / 0.677
3frd DHFDihydrofolate reductase 1.5.1.3 0.672
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.657
1dds MTXDihydrofolate reductase 1.5.1.3 0.655
1jol FFODihydrofolate reductase 1.5.1.3 0.655
3lnc 5GPGuanylate kinase / 0.655
1toi HCIAspartate aminotransferase 2.6.1.1 0.653
1dr3 HBIDihydrofolate reductase 1.5.1.3 0.652
1r4l XX5Angiotensin-converting enzyme 2 3.4.17.23 0.650