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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m6j NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m6j NDPDihydrofolate reductase 1.5.1.3 1.227
8dfr NDPDihydrofolate reductase 1.5.1.3 0.947
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.932
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.931
3nxx NDPDihydrofolate reductase 1.5.1.3 0.930
2w3b NDPDihydrofolate reductase 1.5.1.3 0.921
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.904
1m78 NDPDihydrofolate reductase 1.5.1.3 0.898
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.881
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.881
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.880
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.853
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.849
5ecc NAPDehydrofolate reductase type I / 0.835
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.807
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.804
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.796
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.793
3tqa NDPDihydrofolate reductase / 0.792
1drh NAPDihydrofolate reductase 1.5.1.3 0.783
3qls NDPDihydrofolate reductase 1.5.1.3 0.780
3qlr NDPDihydrofolate reductase 1.5.1.3 0.777
3d84 NDPDihydrofolate reductase 1.5.1.3 0.775
2cig 1DGDihydrofolate reductase 1.5.1.3 0.764
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.762
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.746
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.741
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.736
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.729
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.718
2xw7 NDPDihydrofolate reductase / 0.710
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.708
1rx8 NAPDihydrofolate reductase 1.5.1.3 0.706
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.705
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.688
4xt4 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.683
2azn NAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase / 0.660