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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m15 ADP Tyrosine-protein kinase ITK/TSK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.874
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.693
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.679
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.674
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.673
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.670
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.658
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.656
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.655
2wgh DTPRibonucleoside-diphosphate reductase large subunit 1.17.4.1 0.654
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652