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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lxm 1YU Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4lxm 1YUBeta-secretase 1 3.4.23.46 1.190
4lxa 1YSBeta-secretase 1 3.4.23.46 1.121
4lxk 1YTBeta-secretase 1 3.4.23.46 1.093
4d89 BXDBeta-secretase 1 3.4.23.46 1.061
3vg1 0GTBeta-secretase 1 3.4.23.46 0.915
3vf3 0GSBeta-secretase 1 3.4.23.46 0.911
3k5c 0BIBeta-secretase 1 3.4.23.46 0.906
4i0h 1BLBeta-secretase 1 3.4.23.46 0.905
3qbh QBHBeta-secretase 1 3.4.23.46 0.880
2hm1 LIQBeta-secretase 1 3.4.23.46 0.875
3pi5 3P5Beta-secretase 1 3.4.23.46 0.863
3veu 0GOBeta-secretase 1 3.4.23.46 0.863
3nsh 957Beta-secretase 1 3.4.23.46 0.857
4i0i 957Beta-secretase 1 3.4.23.46 0.857
2iqg F2IBeta-secretase 1 3.4.23.46 0.849
3cib 314Beta-secretase 1 3.4.23.46 0.845
2b8v 3BNBeta-secretase 1 3.4.23.46 0.834
3k5g BJCBeta-secretase 1 3.4.23.46 0.832
4dus 0MPBeta-secretase 1 3.4.23.46 0.824
4ewo 996Beta-secretase 1 3.4.23.46 0.821
4exg 916Beta-secretase 1 3.4.23.46 0.817
4ke0 1R8Beta-secretase 1 3.4.23.46 0.815
2vie VG0Beta-secretase 1 3.4.23.46 0.811
3ohh 3HHBeta-secretase 1 3.4.23.46 0.808
2vnn CM7Beta-secretase 1 3.4.23.46 0.805
4dpi 0N1Beta-secretase 1 3.4.23.46 0.791
3qi1 C6ABeta-secretase 1 3.4.23.46 0.790
3lpi Z74Beta-secretase 1 3.4.23.46 0.789
4k9h 1QUBeta-secretase 1 3.4.23.46 0.789
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.775
4ke1 1R6Beta-secretase 1 3.4.23.46 0.771
2hiz LIJBeta-secretase 1 3.4.23.46 0.763
2p83 MR0Beta-secretase 1 3.4.23.46 0.760
4dh6 0KNBeta-secretase 1 3.4.23.46 0.755
1w51 L01Beta-secretase 1 3.4.23.46 0.752
4i0j 842Beta-secretase 1 3.4.23.46 0.751
3ohf 3HFBeta-secretase 1 3.4.23.46 0.750
3n4l 842Beta-secretase 1 3.4.23.46 0.735
3r2f PB0Beta-secretase 1 3.4.23.46 0.732
2vkm BSDBeta-secretase 1 3.4.23.46 0.721
2vnm CM8Beta-secretase 1 3.4.23.46 0.703
4k8s 1QTBeta-secretase 1 3.4.23.46 0.697
3pww ROCEndothiapepsin 3.4.23.22 0.679
2viz VG4Beta-secretase 1 3.4.23.46 0.677
3lpj Z75Beta-secretase 1 3.4.23.46 0.667
2xfj VG5Beta-secretase 1 3.4.23.46 0.664
2vj6 VG5Beta-secretase 1 3.4.23.46 0.663
3l5e BDWBeta-secretase 1 3.4.23.46 0.663
2viy VG3Beta-secretase 1 3.4.23.46 0.662
3dv1 AR9Beta-secretase 1 3.4.23.46 0.662
2f3f AXFBeta-secretase 1 3.4.23.46 0.651