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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lxk 1YT Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4lxk 1YTBeta-secretase 1 3.4.23.46 1.164
4lxa 1YSBeta-secretase 1 3.4.23.46 1.145
4lxm 1YUBeta-secretase 1 3.4.23.46 1.093
4d89 BXDBeta-secretase 1 3.4.23.46 1.083
3vg1 0GTBeta-secretase 1 3.4.23.46 0.943
3veu 0GOBeta-secretase 1 3.4.23.46 0.934
3vf3 0GSBeta-secretase 1 3.4.23.46 0.933
3qbh QBHBeta-secretase 1 3.4.23.46 0.927
3cib 314Beta-secretase 1 3.4.23.46 0.923
3k5c 0BIBeta-secretase 1 3.4.23.46 0.894
3pi5 3P5Beta-secretase 1 3.4.23.46 0.892
2hm1 LIQBeta-secretase 1 3.4.23.46 0.876
3k5g BJCBeta-secretase 1 3.4.23.46 0.876
4i0h 1BLBeta-secretase 1 3.4.23.46 0.871
2iqg F2IBeta-secretase 1 3.4.23.46 0.866
3ohh 3HHBeta-secretase 1 3.4.23.46 0.856
3lpk Z76Beta-secretase 1 3.4.23.46 0.855
3lpj Z75Beta-secretase 1 3.4.23.46 0.841
3nsh 957Beta-secretase 1 3.4.23.46 0.841
4i0i 957Beta-secretase 1 3.4.23.46 0.841
4dpi 0N1Beta-secretase 1 3.4.23.46 0.835
4exg 916Beta-secretase 1 3.4.23.46 0.835
4ke1 1R6Beta-secretase 1 3.4.23.46 0.823
4ewo 996Beta-secretase 1 3.4.23.46 0.820
2b8v 3BNBeta-secretase 1 3.4.23.46 0.818
3dv5 BAVBeta-secretase 1 3.4.23.46 0.818
4ke0 1R8Beta-secretase 1 3.4.23.46 0.805
4dus 0MPBeta-secretase 1 3.4.23.46 0.804
3qi1 C6ABeta-secretase 1 3.4.23.46 0.801
2vnn CM7Beta-secretase 1 3.4.23.46 0.800
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.791
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.786
3ohf 3HFBeta-secretase 1 3.4.23.46 0.786
2hiz LIJBeta-secretase 1 3.4.23.46 0.785
2p83 MR0Beta-secretase 1 3.4.23.46 0.785
2xfi XFIBeta-secretase 1 3.4.23.46 0.785
3cid 318Beta-secretase 1 3.4.23.46 0.782
2xfj VG5Beta-secretase 1 3.4.23.46 0.780
2xfk AA9Beta-secretase 1 3.4.23.46 0.777
4fco 0U4Beta-secretase 1 3.4.23.46 0.775
1w51 L01Beta-secretase 1 3.4.23.46 0.769
2viy VG3Beta-secretase 1 3.4.23.46 0.766
2p8h MY9Beta-secretase 1 3.4.23.46 0.756
4dh6 0KNBeta-secretase 1 3.4.23.46 0.755
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.751
4e5i 0N9Polymerase acidic protein / 0.744
4i0j 842Beta-secretase 1 3.4.23.46 0.730
4k9h 1QUBeta-secretase 1 3.4.23.46 0.724
2vkm BSDBeta-secretase 1 3.4.23.46 0.722
2wez ZYEBeta-secretase 1 3.4.23.46 0.706
3n4l 842Beta-secretase 1 3.4.23.46 0.705
3skg PB8Beta-secretase 1 3.4.23.46 0.702
3lpi Z74Beta-secretase 1 3.4.23.46 0.701
3l5e BDWBeta-secretase 1 3.4.23.46 0.660
3cic 316Beta-secretase 1 3.4.23.46 0.658
4k8s 1QTBeta-secretase 1 3.4.23.46 0.655
1e80 0GQEndothiapepsin 3.4.23.22 0.650