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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lv7 ADP Inositol-pentakisphosphate 2-kinase 2.7.1.158

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 1.048
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.832
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.829
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.821
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.783
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.781
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.755
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.742
4ceg ADPAurora kinase A 2.7.11.1 0.736
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.735
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.729
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.726
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.724
2pul ACPMethylthioribose kinase 2.7.1.100 0.724
1u54 ACPActivated CDC42 kinase 1 / 0.713
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.712
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.710
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.708
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.705
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.704
1mq4 ADPAurora kinase A 2.7.11.1 0.701
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.697
4zgn ATPCell division cycle protein 123 / 0.696
5dr2 ATPAurora kinase A 2.7.11.1 0.696
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.695
2pui ADPMethylthioribose kinase 2.7.1.100 0.695
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.695
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.694
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.693
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.693
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.693
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.693
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.690
4dee ADPAurora kinase A 2.7.11.1 0.690
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.689
3c4z ADPRhodopsin kinase / 0.689
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
3qc9 ADPRhodopsin kinase / 0.686
4bn1 ADPAurora kinase A 2.7.11.1 0.686
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.686
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.684
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.683
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.683
3ort AGSSerine/threonine protein kinase / 0.683
4c3r ACPAurora kinase A 2.7.11.1 0.682
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.681
2pup ADPMethylthioribose kinase 2.7.1.100 0.681
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.681
5iqf GDPBifunctional AAC/APH 2.3.1 0.681
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.680
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.679
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.679
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.678
4fu0 ADPD-alanine--D-alanine ligase / 0.677
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.677
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.676
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.676
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.675
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.674
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.674
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.674
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.673
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.673
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.673
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.672
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.670
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.670
4utd ACPAurora kinase A 2.7.11.1 0.670
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2dwb ANPAurora kinase A 2.7.11.1 0.668
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.668
5dt3 ATPAurora kinase A 2.7.11.1 0.668
5l8j ADPAurora kinase A 2.7.11.1 0.668
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.667
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.666
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.666
3tdv GDPGentamicin resistance protein / 0.665
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.665
3orp AGSSerine/threonine protein kinase / 0.664
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.664
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.664
2pun ACPMethylthioribose kinase 2.7.1.100 0.663
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.663
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.663
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.662
3t8o ATPRhodopsin kinase / 0.662
2qen ADPWalker-Type ATPase / 0.661
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.661
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.661
5dn3 ATPAurora kinase A 2.7.11.1 0.661
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.660
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.660
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.659
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4q5h ANPProtein kinase OspG 2.7 0.659
4xlv ACPInsulin receptor 2.7.10.1 0.659
2zdg ADPD-alanine--D-alanine ligase / 0.658
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.658
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.658
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.657
5eg3 ACPFibroblast growth factor receptor 2 / 0.657
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.656
3c50 ADPRhodopsin kinase / 0.656
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.656
1ir3 ANPInsulin receptor 2.7.10.1 0.655
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.655
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.654
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.653
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.652
1i44 ACPInsulin receptor 2.7.10.1 0.652
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.652
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.652
1bxr ANPCarbamoyl-phosphate synthase large chain / 0.651
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.651
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.651
1h8h ADPATP synthase subunit alpha, mitochondrial / 0.650
1h8h ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.650
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4qny ANPMitogen activated protein kinase, putative / 0.650