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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kne 1CY Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4kne 1CYDihydrofolate reductase 1.5.1.3 0.868
3um6 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.696
3irm 1CYBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.665
3qfx CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.656
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.655
3um8 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.654
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.652