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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4keb FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4keb FOLDihydrofolate reductase 1.5.1.3 1.032
4m6k FOLDihydrofolate reductase 1.5.1.3 1.000
2w3m FOLDihydrofolate reductase 1.5.1.3 0.984
4kfj FOLDihydrofolate reductase 1.5.1.3 0.936
1dhf FOLDihydrofolate reductase 1.5.1.3 0.900
1hfq MOTDihydrofolate reductase 1.5.1.3 0.846
3eig MTXDihydrofolate reductase 1.5.1.3 0.813
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.810
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.808
4i1n FOLDihydrofolate reductase 1.5.1.3 0.802
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.801
1drf FOLDihydrofolate reductase 1.5.1.3 0.797
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.794
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.794
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.793
4kjj FOLDihydrofolate reductase 1.5.1.3 0.793
4m6l 21VDihydrofolate reductase 1.5.1.3 0.790
3dau MTXDihydrofolate reductase 1.5.1.3 0.786
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.781
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.778
4x5g FOLDihydrofolate reductase 1.5.1.3 0.777
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.775
3tqb FOLDihydrofolate reductase / 0.772
1hfr MOTDihydrofolate reductase 1.5.1.3 0.771
1hfp MOTDihydrofolate reductase 1.5.1.3 0.770
7dfr FOLDihydrofolate reductase 1.5.1.3 0.770
2qk8 MTXDihydrofolate reductase / 0.769
3tq9 MTXDihydrofolate reductase / 0.769
4x5f FOLDihydrofolate reductase 1.5.1.3 0.769
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.768
1dyh DZFDihydrofolate reductase 1.5.1.3 0.762
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.758
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.755
4x5h FOLDihydrofolate reductase 1.5.1.3 0.755
5hi6 MTXDihydrofolate reductase / 0.753
2d0k FOLDihydrofolate reductase 1.5.1.3 0.751
4qi9 MTXDihydrofolate reductase / 0.749
4i13 FOLDihydrofolate reductase 1.5.1.3 0.748
1dhi MTXDihydrofolate reductase 1.5.1.3 0.747
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.745
1u70 MTXDihydrofolate reductase 1.5.1.3 0.745
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.741
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.740
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.740
1ohk COPDihydrofolate reductase 1.5.1.3 0.736
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.735
3och 2MXDihydrofolate reductase 1.5.1.3 0.734
3dfr MTXDihydrofolate reductase 1.5.1.3 0.731
1drb MTXDihydrofolate reductase 1.5.1.3 0.730
1dre MTXDihydrofolate reductase 1.5.1.3 0.730
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.729
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.729
3ghw GHWDihydrofolate reductase 1.5.1.3 0.729
1jom FFODihydrofolate reductase 1.5.1.3 0.728
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.725
1df7 MTXDihydrofolate reductase 1.5.1.3 0.722
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.721
1u72 MTXDihydrofolate reductase 1.5.1.3 0.721
2zza FOLDihydrofolate reductase / 0.721
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.716
4p68 MTXDihydrofolate reductase / 0.715
1dra MTXDihydrofolate reductase 1.5.1.3 0.713
4x5i FOLDihydrofolate reductase 1.5.1.3 0.713
1dyi FOLDihydrofolate reductase 1.5.1.3 0.712
1re7 FOLDihydrofolate reductase 1.5.1.3 0.712
3drc MTXDihydrofolate reductase 1.5.1.3 0.712
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.711
3ia4 MTXDihydrofolate reductase / 0.706
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.703
1dyj DDFDihydrofolate reductase 1.5.1.3 0.702
1tdr MTXDihydrofolate reductase 1.5.1.3 0.702
1ohj COPDihydrofolate reductase 1.5.1.3 0.699
4dfr MTXDihydrofolate reductase 1.5.1.3 0.699
3frd DHFDihydrofolate reductase 1.5.1.3 0.698
1jol FFODihydrofolate reductase 1.5.1.3 0.697
2dhf DZFDihydrofolate reductase 1.5.1.3 0.697
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.696
4p66 MTXDihydrofolate reductase / 0.694
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.693
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.691
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.684
3ghv GHCDihydrofolate reductase 1.5.1.3 0.683
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.677
4fhb FOLDihydrofolate reductase 1.5.1.3 0.672
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.671
1e26 GPBDihydrofolate reductase 1.5.1.3 0.667
1dls MTXDihydrofolate reductase 1.5.1.3 0.666
3nxo D2BDihydrofolate reductase 1.5.1.3 0.666
4kak 06UDihydrofolate reductase 1.5.1.3 0.660
1dds MTXDihydrofolate reductase 1.5.1.3 0.657
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.657
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.656
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.654
3gyf 51PDihydrofolate reductase 1.5.1.3 0.651