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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4k9y K9Y Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4k9y K9YFocal adhesion kinase 1 2.7.10.2 1.238
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.890
3hv3 R49Mitogen-activated protein kinase 14 / 0.806
3hv6 R39Mitogen-activated protein kinase 14 / 0.797
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.791
1w82 L10Mitogen-activated protein kinase 14 / 0.773
3gcq 1BUMitogen-activated protein kinase 14 / 0.769
2yiw YIWMitogen-activated protein kinase 14 / 0.755
2yis YISMitogen-activated protein kinase 14 / 0.754
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.754
3lfb Z87Mitogen-activated protein kinase 14 / 0.748
3lff Z83Mitogen-activated protein kinase 14 / 0.748
3nnx EDDMitogen-activated protein kinase 14 / 0.744
3pg3 DG7Mitogen-activated protein kinase 14 / 0.741
3hv4 L51Mitogen-activated protein kinase 14 / 0.737
3uvr 06FMitogen-activated protein kinase 14 / 0.731
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.729
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.729
2puu G2GMitogen-activated protein kinase 14 / 0.728
3hv5 R24Mitogen-activated protein kinase 14 / 0.726
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.720
3nnw EDDMitogen-activated protein kinase 14 / 0.719
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.718
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.716
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.712
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.707
3o8t BMUMitogen-activated protein kinase 14 / 0.703
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.695
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.693
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.685
1kv2 B96Mitogen-activated protein kinase 14 / 0.683
3hv7 1AUMitogen-activated protein kinase 14 / 0.681
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.681
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.679
1kv1 BMUMitogen-activated protein kinase 14 / 0.672
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.669
3p78 P78Mitogen-activated protein kinase 14 / 0.666
3p79 P79Mitogen-activated protein kinase 14 / 0.665
3gcv SS6Mitogen-activated protein kinase 14 / 0.663
3nnu EDBMitogen-activated protein kinase 14 / 0.663
3lfe Z84Mitogen-activated protein kinase 14 / 0.658
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.652
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.652
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.650