Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4juc TPP Benzoylformate decarboxylase 4.1.1.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4juc TPPBenzoylformate decarboxylase 4.1.1.7 1.275
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 1.107
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 1.105
4jub TPPBenzoylformate decarboxylase 4.1.1.7 1.099
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 1.093
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 1.074
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 1.037
4juf TPPBenzoylformate decarboxylase 4.1.1.7 1.035
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 1.014
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.999
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.995
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.994
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.992
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.991
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.985
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.975
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.968
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.964
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.952
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.926
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.922
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.920
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.913
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.906
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.898
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.894
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.840
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.820
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.803
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.792
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.791
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.783
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.781
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.780
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.780
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.780
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.776
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.774
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.773
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.771
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.768
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.766
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.763
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.762
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.761
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.761
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.760
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.758
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.758
5ahk TPPAcetolactate synthase II, large subunit / 0.758
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.757
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.755
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.754
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.754
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.754
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.752
3upt TPPTransketolase / 0.751
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.750
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.750
1y9d TPPPyruvate oxidase 1.2.3.3 0.749
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.745
4cok TPPPyruvate decarboxylase / 0.744
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.744
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.740
1pow TPPPyruvate oxidase 1.2.3.3 0.738
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.734
2r8o T5XTransketolase 1 / 0.733
1pox TPPPyruvate oxidase 1.2.3.3 0.730
2r5n TPPTransketolase 1 / 0.730
2uz1 TPPBenzaldehyde lyase / 0.729
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.728
3m34 TPPTransketolase / 0.727
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.726
1tkc M6TTransketolase 1 2.2.1.1 0.722
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.721
3iae D7KBenzaldehyde lyase / 0.719
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.717
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.717
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.717
1gpu THDTransketolase 1 2.2.1.1 0.715
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.715
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.715
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.714
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.714
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.714
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.714
1ngs TPPTransketolase 1 2.2.1.1 0.711
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.709
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.708
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.708
1ay0 TPPTransketolase 1 2.2.1.1 0.707
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.707
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.707
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.707
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.704
3m6l TPPTransketolase / 0.704
1trk TPPTransketolase 1 2.2.1.1 0.702
2pan TDPGlyoxylate carboligase 4.1.1.47 0.702
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.701
2ag0 TPPBenzaldehyde lyase / 0.700
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.700
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.700
2ji6 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.696
3ahe THDProbable phosphoketolase / 0.695
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.694
3rim TPPTransketolase 2.2.1.1 0.693
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.692
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.692
3ahi HTLProbable phosphoketolase / 0.691
2ezt TDMPyruvate oxidase 1.2.3.3 0.686
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.686
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.683
2c42 TPPPyruvate synthase / 0.681
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.680
2ez9 TDKPyruvate oxidase 1.2.3.3 0.679
2c3u 2TPPyruvate synthase / 0.678
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.674
2c3o TPPPyruvate synthase / 0.672
5c4i TPPOxalate oxidoreductase subunit alpha / 0.661
5c4i TPPOxalate oxidoreductase subunit beta / 0.661
4c7x TPPTransketolase / 0.660
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.657
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.657
3m7i TPPTransketolase / 0.657
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.655
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.654
3ahj TPPProbable phosphoketolase / 0.654
4tuy GTPTubulin alpha-1B chain / 0.654
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.652
2ag1 TPPBenzaldehyde lyase / 0.650