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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jlc SU6 Serine/threonine-protein kinase TBK1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 1.051
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.728
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.725
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.714
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.692
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.675
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.659
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.658
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.654