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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j98 ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j98 ACPFibroblast growth factor receptor 2 / 0.836
2pzp ACPFibroblast growth factor receptor 2 / 0.717
2pz5 ACPFibroblast growth factor receptor 2 / 0.712
2py3 ACPFibroblast growth factor receptor 2 / 0.711
3b2t M33Fibroblast growth factor receptor 2 / 0.706
5eg3 ACPFibroblast growth factor receptor 2 / 0.704
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.699
4j97 ACPFibroblast growth factor receptor 2 / 0.694
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.684
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.681
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.680
5l8l ADPAurora kinase A 2.7.11.1 0.676
2pvy ACPFibroblast growth factor receptor 2 / 0.675
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.673
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.670
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.669
5l8j ADPAurora kinase A 2.7.11.1 0.662
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.659
5l8k ADPAurora kinase A 2.7.11.1 0.659
2olc ADPMethylthioribose kinase 2.7.1.100 0.655
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.653
2pwl ACPFibroblast growth factor receptor 2 / 0.653
3cly ACPFibroblast growth factor receptor 2 / 0.652
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4xhg ADPUncharacterized protein / 0.652
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.651
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.650
2vgo AD5Aurora kinase B-A 2.7.11.1 0.650
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.650
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650