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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j95 ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j95 ACPFibroblast growth factor receptor 2 / 0.841
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.678
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
3b2t M33Fibroblast growth factor receptor 2 / 0.671
4j99 ACPFibroblast growth factor receptor 2 / 0.666
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.664
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.662
2vgo AD5Aurora kinase B-A 2.7.11.1 0.659
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.656
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.651
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2wqe ADPAurora kinase A 2.7.11.1 0.650