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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j43 NAD Uncharacterized protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j43 NADUncharacterized protein / 1.117
4j49 NADUncharacterized protein / 1.079
4jk3 NADUncharacterized protein / 1.030
4j49 NAIUncharacterized protein / 1.024
4j4b NAIUncharacterized protein / 0.968
4c4o NADSADH / 0.809
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.801
1uxj NADMalate dehydrogenase / 0.791
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.784
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.782
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.781
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.778
1pzh NADLactate dehydrogenase / 0.776
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.776
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.772
1sow NADL-lactate dehydrogenase 1.1.1.27 0.770
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.769
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.768
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.766
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.765
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.763
3wle NAD(R)-specific carbonyl reductase / 0.763
2gsd NADFormate dehydrogenase / 0.759
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.756
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.753
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.750
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.750
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.749
3oet NADErythronate-4-phosphate dehydrogenase / 0.748
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.748
1x7d NADPutative ornithine cyclodeaminase / 0.747
1uxk NADMalate dehydrogenase / 0.744
1pzg A3DLactate dehydrogenase / 0.743
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.743
3jv7 NADSecondary alcohol dehydrogenase / 0.743
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.743
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.739
1ib6 NADMalate dehydrogenase / 0.738
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.737
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.736
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.735
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.735
1u7h NADPutative ornithine cyclodeaminase / 0.734
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.734
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.732
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.731
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.730
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.730
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.728
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.727
3wsw NADL-lactate dehydrogenase / 0.727
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.726
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.723
2vhx NADAlanine dehydrogenase 1.4.1.1 0.723
2voj NADAlanine dehydrogenase 1.4.1.1 0.723
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.723
1o6z NADMalate dehydrogenase / 0.721
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.721
2xaa NADSecondary alcohol dehydrogenase / 0.720
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.720
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.720
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.719
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
2nad NADFormate dehydrogenase / 0.718
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
2x0i NAIMalate dehydrogenase / 0.718
4tvb NADHomospermidine synthase 2.5.1.44 0.718
4xrg NADHomospermidine synthase 2.5.1.44 0.718
4b7x NAPProbable oxidoreductase / 0.717
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.716
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.716
5a1t NAIL-lactate dehydrogenase / 0.716
4cpd NADAlcohol dehydrogenase / 0.715
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.715
4xqc NADHomospermidine synthase 2.5.1.44 0.714
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.713
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.713
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.710
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.710
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.709
1pjc NADAlanine dehydrogenase / 0.708
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.708
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.707
3two NDPMannitol dehydrogenase / 0.706
4plp NADHomospermidine synthase 2.5.1.44 0.706
4i1i NADMalate dehydrogenase / 0.705
2o4c NADErythronate-4-phosphate dehydrogenase / 0.703
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.701
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.701
1hku NADC-terminal-binding protein 1 1.1.1 0.701
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.701
1wze NADMalate dehydrogenase / 0.700
3kb6 NADD-lactate dehydrogenase / 0.700
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.700
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.699
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.699
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.699
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.699
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.698
4oaq NDPR-specific carbonyl reductase / 0.697
1gv0 NADMalate dehydrogenase / 0.696
4k28 NADShikimate dehydrogenase family protein / 0.696
4xq9 NADHomospermidine synthase 2.5.1.44 0.696
2x0r NADMalate dehydrogenase / 0.695
1bdm NAXMalate dehydrogenase / 0.694
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.694
2d8a NADL-threonine 3-dehydrogenase / 0.694
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.694
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.693
1omo NADAlanine dehydrogenase / 0.692
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.692
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.691
1b8v NADMalate dehydrogenase / 0.688
2dbz NAPGlyoxylate reductase 1.1.1.26 0.688
4l0q NADAlcohol dehydrogenase class-3 / 0.688
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.687
3wv8 ATPHmd co-occurring protein HcgE / 0.685
3d64 NADAdenosylhomocysteinase / 0.684
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.684
2a92 NAIL-lactate dehydrogenase / 0.682
3rf7 NADIron-containing alcohol dehydrogenase / 0.682
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.681
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.681
2aa3 AP0L-lactate dehydrogenase / 0.681
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.680
2dbr NAPGlyoxylate reductase 1.1.1.26 0.680
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.680
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.680
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.680
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.679
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.679
1ie3 NADMalate dehydrogenase / 0.679
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.679
1llu NADAlcohol dehydrogenase / 0.679
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.679
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.679
2vna NAPProstaglandin reductase 2 1.3.1.48 0.678
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.678
2cdc NAPGlucose 1-dehydrogenase / 0.676
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.675
4jji NADAlcohol dehydrogenase class-3 / 0.675
4weq NAPNAD-dependent dehydrogenase / 0.675
3sx2 NADUncharacterized protein / 0.674
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.674
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.672
2dph NADFormaldehyde dismutase / 0.672
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.672
2e37 NADL-lactate dehydrogenase / 0.671
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.671
4gl4 NAIAlcohol dehydrogenase class-3 / 0.671
1b8u NADMalate dehydrogenase / 0.670
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.670
1qor NDPQuinone oxidoreductase 1 / 0.669
2g5c NADPrephenate dehydrogenase / 0.669
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.668
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.668
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.667
3wv7 ADPHmd co-occurring protein HcgE / 0.667
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.666
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.666
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.666
1up6 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.666
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.665
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.664
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.664
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.664
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.664
3gvh NADMalate dehydrogenase / 0.663
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.663
4xye NADFormate dehydrogenase / 0.663
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.662
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.662
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.662
3gvi ADPMalate dehydrogenase / 0.661
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.661
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.660
2dbq NAPGlyoxylate reductase 1.1.1.26 0.660
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.660
2fkn NADUrocanate hydratase 4.2.1.49 0.659
3wid NAPGlucose 1-dehydrogenase / 0.659
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.658
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.658
3ggp NADPrephenate dehydrogenase / 0.658
1bmd NADMalate dehydrogenase / 0.656
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.656
1zmd NAIDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.656
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.656
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.656
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.655
3icr FADCoenzyme A disulfide reductase / 0.655
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.654
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.654
4yac NAIC alpha-dehydrogenase / 0.654
2ejv NADL-threonine 3-dehydrogenase / 0.653
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.653
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
3uko NADAlcohol dehydrogenase class-3 / 0.652
4b69 FADL-ornithine N(5)-monooxygenase / 0.652
1guy NADMalate dehydrogenase / 0.651
4nzh FADL-ornithine N(5)-monooxygenase / 0.651
4z0p NDPNAD-dependent dehydrogenase / 0.651
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.650
1yqd NAPSinapyl alcohol dehydrogenase / 0.650
2b4r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650