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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j26 EST Estrogen receptor beta

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j26 ESTEstrogen receptor beta / 1.180
4j24 ESTEstrogen receptor beta / 1.090
3oll ESTEstrogen receptor beta / 1.055
3ols ESTEstrogen receptor beta / 1.054
2qgt EEDEstrogen receptor / 0.965
3l03 4OHEstrogen receptor / 0.941
5dx3 ESTEstrogen receptor / 0.887
2b1z 17MEstrogen receptor / 0.882
3q95 ESLEstrogen receptor / 0.877
2yat EEUEstrogen receptor / 0.863
2ocf ESTEstrogen receptor / 0.858
2g5o DRQEstrogen receptor / 0.834
2j7x ESTEstrogen receptor beta / 0.784
1l2i ETCEstrogen receptor / 0.769
4pxm ESTEstrogen receptor / 0.733
5hyr ESTEstrogen receptor / 0.728
1gwr ESTEstrogen receptor / 0.718
2aa2 AS4Mineralocorticoid receptor / 0.706
4oez DHTAndrogen receptor / 0.702
1fdt ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.698
1zky 689Estrogen receptor / 0.698
2yja ESTEstrogen receptor / 0.698
1gwq ZTWEstrogen receptor / 0.697
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.697
3gkj HC3Niemann-Pick C1 protein / 0.696
5dxg ESTEstrogen receptor / 0.696
3vhu SNLMineralocorticoid receptor / 0.687
4ofr DHTAndrogen receptor / 0.687
3gki CLRNiemann-Pick C1 protein / 0.686
2piq DHTAndrogen receptor / 0.683
1y5r C0RCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.682
1fdu ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.679
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.676
2q7i TESAndrogen receptor / 0.673
1x7r GENEstrogen receptor / 0.672
2aib ERGBeta-elicitin cinnamomin / 0.672
1ogx EQUSteroid Delta-isomerase 5.3.3.1 0.671
3uud ESTEstrogen receptor / 0.670
4q0a 4OAVitamin D3 receptor A / 0.670
2piu DHTAndrogen receptor / 0.667
1t79 DHTAndrogen receptor / 0.666
2d06 ESTSulfotransferase 1A1 2.8.2.1 0.665
1lhw ESMSex hormone-binding globulin / 0.664
4e5i 0N9Polymerase acidic protein / 0.660
2nv7 555Estrogen receptor beta / 0.659
4e5f 0N7Polymerase acidic protein / 0.659
4pp6 STLEstrogen receptor / 0.659
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.657
2q9f C3SCholesterol 24-hydroxylase / 0.656
3em0 CHDFatty acid-binding protein 6, ileal (gastrotropin) / 0.656
1p8d CO1Oxysterols receptor LXR-beta / 0.651
4a81 DXCMajor pollen allergen Bet v 1-A / 0.650