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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j1e 1HM Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j1e 1HMBeta-secretase 1 3.4.23.46 1.012
4j17 1HQBeta-secretase 1 3.4.23.46 0.919
4j0z 1H5Beta-secretase 1 3.4.23.46 0.849
4j1c 1HOBeta-secretase 1 3.4.23.46 0.835
4bfd 8T3Beta-secretase 1 3.4.23.46 0.817
4j1f 1HLBeta-secretase 1 3.4.23.46 0.817
4j1k 1HGBeta-secretase 1 3.4.23.46 0.814
4j0y 1H6Beta-secretase 1 3.4.23.46 0.788
4j1i 1HHBeta-secretase 1 3.4.23.46 0.788
4j0p 1H8Beta-secretase 1 3.4.23.46 0.783
3zmg 6Z0Beta-secretase 1 3.4.23.46 0.782
3zov WZVBeta-secretase 1 3.4.23.46 0.779
3zki WZVBeta-secretase 2 3.4.23.45 0.776
4j1h 1HJBeta-secretase 1 3.4.23.46 0.765
4j0t 6T9Beta-secretase 1 3.4.23.46 0.745
3zks WZVBeta-secretase 2 3.4.23.45 0.729
4j0v 1H7Beta-secretase 1 3.4.23.46 0.713
4frs 0V6Beta-secretase 1 3.4.23.46 0.677
3zlq 6T9Beta-secretase 2 3.4.23.45 0.676
4fs4 H24Beta-secretase 1 3.4.23.46 0.667
4b1e 6T6Beta-secretase 1 3.4.23.46 0.661
3d83 GK6Mitogen-activated protein kinase 14 / 0.660
4l7g 1W0Beta-secretase 1 3.4.23.46 0.655