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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ivd 15T Tyrosine-protein kinase JAK1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ivd 15TTyrosine-protein kinase JAK1 / 0.997
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.940
4ivb 1J5Tyrosine-protein kinase JAK1 / 0.935
4iva 1J5Tyrosine-protein kinase JAK2 / 0.878
4ei4 0Q2Tyrosine-protein kinase JAK1 / 0.790
4e4l 0NHTyrosine-protein kinase JAK1 / 0.780
4f09 JAKTyrosine-protein kinase JAK2 / 0.764
4ehz JAKTyrosine-protein kinase JAK1 / 0.763
4i5c C5ITyrosine-protein kinase JAK1 / 0.744
4e6q 0NVTyrosine-protein kinase JAK2 / 0.734
4e5w 0NTTyrosine-protein kinase JAK1 / 0.709
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.682
3k5u PFQAurora kinase A 2.7.11.1 0.662
4e6d 0NUTyrosine-protein kinase JAK2 / 0.659
4ewh T77Activated CDC42 kinase 1 / 0.654
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.651