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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iue AJ4 Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iue AJ4Tankyrase-2 2.4.2.30 0.970
4j21 AJ6Tankyrase-2 2.4.2.30 0.889
4j22 AJ7Tankyrase-2 2.4.2.30 0.875
4j3m AJ8Tankyrase-2 2.4.2.30 0.834
4avu LDRTankyrase-2 2.4.2.30 0.801
4j3l AJ5Tankyrase-2 2.4.2.30 0.719
4bjb P34Tankyrase-2 2.4.2.30 0.710
4avw G18Tankyrase-2 2.4.2.30 0.683
4buw F33Tankyrase-2 2.4.2.30 0.670
4bue JQFTankyrase-2 2.4.2.30 0.667
4bus 32FTankyrase-2 2.4.2.30 0.666
4buv 16ITankyrase-2 2.4.2.30 0.665
4l0t 1V0Tankyrase-2 2.4.2.30 0.665
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4l6s 1WQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.659
4buu F38Tankyrase-2 2.4.2.30 0.658
4bux F35Tankyrase-2 2.4.2.30 0.654
4but 31FTankyrase-2 2.4.2.30 0.653
4e5f 0N7Polymerase acidic protein / 0.653
4hlm 16STankyrase-2 2.4.2.30 0.652
4li8 1XQTankyrase-1 2.4.2.30 0.651
4l2f 1V3Tankyrase-2 2.4.2.30 0.650