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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4itb NDP Succinate-semialdehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4itb NDPSuccinate-semialdehyde dehydrogenase / 1.232
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.899
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.877
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.867
4pxl NADAldehyde dehydrogenase3 / 0.860
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.850
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.836
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.831
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.807
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.805
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.793
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.775
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.769
4pt3 NDPAldehyde dehydrogenase / 0.768
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.765
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.753
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.747
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.745
5eyu NADBetaine-aldehyde dehydrogenase / 0.739
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.732
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.708
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.708
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.707
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.706
4i8q NADPutative betaine aldehyde dehyrogenase / 0.705
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.699
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.696
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.695
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.694
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.694
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.694
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.692
5dib NADBetaine-aldehyde dehydrogenase / 0.692
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.691
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.691
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.691
4f3x NADPutative aldehyde dehydrogenase / 0.690
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.689
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.686
4pz2 NADAldehyde dehydrogenase 2-6 / 0.686
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.685
2esd NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.684
3b4w NADAldehyde dehydrogenase family protein / 0.683
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.682
4pt0 NADAldehyde dehydrogenase / 0.682
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.680
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.679
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.679
4i3v NADAldehyde dehydrogenase (NAD+) / 0.679
5ez4 NADBetaine-aldehyde dehydrogenase / 0.678
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.675
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.675
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.674
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.670
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.670
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.665
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.664
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.661
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.660
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.660
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.659
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.657
3iwj NADAminoaldehyde dehydrogenase / 0.656
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.655
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651