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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4im0 1FV Serine/threonine-protein kinase TBK1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4im0 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 1.056
4iwq 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.786
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.745
4iwo 1H4Serine/threonine-protein kinase TBK1 2.7.11.1 0.725
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.687
1oec AA2Fibroblast growth factor receptor 2 / 0.684
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.661
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.658