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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iir ANP Serine/threonine-protein kinase PRP4 homolog 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 1.007
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.858
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.769
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.754
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.753
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.742
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.742
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.740
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.740
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
4xlv ACPInsulin receptor 2.7.10.1 0.735
4qny ANPMitogen activated protein kinase, putative / 0.734
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.733
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.731
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.731
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.730
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.728
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.727
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.727
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.722
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.721
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.720
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.719
2olc ADPMethylthioribose kinase 2.7.1.100 0.719
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.716
1cm8 ANPMitogen-activated protein kinase 12 / 0.714
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.713
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.713
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.712
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.712
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.711
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.711
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.708
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.705
4ceg ADPAurora kinase A 2.7.11.1 0.704
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.704
5dt3 ATPAurora kinase A 2.7.11.1 0.704
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.703
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.701
2pul ACPMethylthioribose kinase 2.7.1.100 0.700
2pun ACPMethylthioribose kinase 2.7.1.100 0.700
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.699
5dn3 ATPAurora kinase A 2.7.11.1 0.699
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.698
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.698
5eg3 ACPFibroblast growth factor receptor 2 / 0.698
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.697
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.697
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.695
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.694
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.694
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.694
4utd ACPAurora kinase A 2.7.11.1 0.694
3rv4 ADPBiotin carboxylase 6.3.4.14 0.693
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.693
5dr2 ATPAurora kinase A 2.7.11.1 0.693
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.691
2pml ANPUncharacterized protein / 0.689
2zdg ADPD-alanine--D-alanine ligase / 0.688
4bn1 ADPAurora kinase A 2.7.11.1 0.688
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.688
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.687
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.686
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.686
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.685
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.685
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.685
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
3a8w ATPProtein kinase C iota type 2.7.11.13 0.684
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.682
4dee ADPAurora kinase A 2.7.11.1 0.682
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.681
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.681
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.680
2py3 ACPFibroblast growth factor receptor 2 / 0.679
2pui ADPMethylthioribose kinase 2.7.1.100 0.678
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
4q5h ANPProtein kinase OspG 2.7 0.678
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.677
4c3r ACPAurora kinase A 2.7.11.1 0.677
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.676
5dt4 ATPAurora kinase A 2.7.11.1 0.676
2pz5 ACPFibroblast growth factor receptor 2 / 0.675
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.675
1m0w ANPGlutathione synthetase 6.3.2.3 0.674
3t8o ATPRhodopsin kinase / 0.674
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.673
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5dos ATPAurora kinase A 2.7.11.1 0.673
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.672
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.672
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.671
3nie ANPMitogen-activated protein kinase / 0.670
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.669
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.669
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.669
1ol6 ATPAurora kinase A 2.7.11.1 0.668
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.668
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.668
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.668
2dwb ANPAurora kinase A 2.7.11.1 0.666
3c4z ADPRhodopsin kinase / 0.666
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.666
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.666
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.665
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.665
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.664
4gyi ADPUncharacterized protein / 0.664
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.664
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.664
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.663
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.663
4o4f ATPKinase / 0.662
5ce3 ADPProtein kinase YopO / 0.662
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.661
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
4o4e ATPKinase / 0.661
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.661
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.659
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.659
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.659
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.659
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.658
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.657
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
1id0 ANPSensor protein PhoQ 2.7.13.3 0.656
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.656
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.656
4ffl ADPUncharacterized protein / 0.656
1ol5 ADPAurora kinase A 2.7.11.1 0.655
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
3bu5 ATPInsulin receptor 2.7.10.1 0.654
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.654
5drd ATPAurora kinase A 2.7.11.1 0.654
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.653
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.653
4o4d ATPKinase / 0.653
1i44 ACPInsulin receptor 2.7.10.1 0.652
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.652
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.652
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.651
2pup ADPMethylthioribose kinase 2.7.1.100 0.651
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.651
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.651
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.651
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.650
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.650
3tw6 ADPPyruvate carboxylase / 0.650