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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ifc ADP Serine/threonine-protein kinase PRP4 homolog 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.962
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.858
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.797
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.786
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.765
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.756
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.755
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.753
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.751
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.750
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
4qny ANPMitogen activated protein kinase, putative / 0.743
3rv4 ADPBiotin carboxylase 6.3.4.14 0.742
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.741
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.739
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.736
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.735
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.735
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.731
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.731
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.730
1cm8 ANPMitogen-activated protein kinase 12 / 0.729
2olc ADPMethylthioribose kinase 2.7.1.100 0.728
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.727
2pun ACPMethylthioribose kinase 2.7.1.100 0.726
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.724
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.721
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.720
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.719
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.718
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.716
2py3 ACPFibroblast growth factor receptor 2 / 0.715
2pul ACPMethylthioribose kinase 2.7.1.100 0.714
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.713
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.711
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.710
2dwb ANPAurora kinase A 2.7.11.1 0.709
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.708
3t8o ATPRhodopsin kinase / 0.708
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.707
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.706
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.705
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.705
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.703
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.703
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.703
4xlv ACPInsulin receptor 2.7.10.1 0.703
2pyw ADPMethylthioribose kinase 2.7.1.100 0.702
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.702
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.700
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.700
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.699
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.696
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.696
2pui ADPMethylthioribose kinase 2.7.1.100 0.696
4dee ADPAurora kinase A 2.7.11.1 0.696
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
2pz5 ACPFibroblast growth factor receptor 2 / 0.695
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.695
2pml ANPUncharacterized protein / 0.694
2pzp ACPFibroblast growth factor receptor 2 / 0.694
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.693
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.693
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.693
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.693
5eg3 ACPFibroblast growth factor receptor 2 / 0.693
3a8w ATPProtein kinase C iota type 2.7.11.13 0.692
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.692
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.692
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.690
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.688
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
3orm AGSSerine/threonine protein kinase / 0.686
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.685
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.685
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.683
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.682
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.680
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.680
5dr2 ATPAurora kinase A 2.7.11.1 0.680
2j9g ADPBiotin carboxylase 6.3.4.14 0.679
5ckw ANPUncharacterized protein / 0.679
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.678
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.677
4o4e ATPKinase / 0.677
2pup ADPMethylthioribose kinase 2.7.1.100 0.676
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.676
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.676
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.675
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.674
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.673
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.673
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.673
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.673
5c93 ACPTwo-component system histidine protein kinase / 0.673
1ol6 ATPAurora kinase A 2.7.11.1 0.672
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.671
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.670
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.669
1id0 ANPSensor protein PhoQ 2.7.13.3 0.668
4utd ACPAurora kinase A 2.7.11.1 0.668
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
3c4z ADPRhodopsin kinase / 0.667
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.666
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.666
4q5h ANPProtein kinase OspG 2.7 0.666
4bix ADPSensor histidine kinase CpxA / 0.665
4gyi ADPUncharacterized protein / 0.665
3c4w ATPRhodopsin kinase / 0.664
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.664
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.664
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.664
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.664
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.663
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.663
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.663
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.663
4ceg ADPAurora kinase A 2.7.11.1 0.662
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.661
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.661
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.660
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.660
3cly ACPFibroblast growth factor receptor 2 / 0.660
3q5i ANPProtein kinase, putative / 0.660
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.660
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.659
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.659
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3llt ANPProtein serine/threonine kinase-1 / 0.658
4bn1 ADPAurora kinase A 2.7.11.1 0.658
5dn3 ATPAurora kinase A 2.7.11.1 0.658
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.657
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.656
2o8b ADPDNA mismatch repair protein Msh2 / 0.656
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.656
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.656
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.655
5dnr ATPAurora kinase A 2.7.11.1 0.655
1ol7 ADPAurora kinase A 2.7.11.1 0.654
5ce3 ADPProtein kinase YopO / 0.654
1ol5 ADPAurora kinase A 2.7.11.1 0.653
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.653
4c3r ACPAurora kinase A 2.7.11.1 0.652
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.652
1wc6 TATAdenylate cyclase / 0.651
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.651
4zol ACPTubulin tyrosine ligase / 0.651
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.650
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.650
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.650
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.650