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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ie5 MD6 Alpha-ketoglutarate-dependent dioxygenase FTO

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.863
4ie6 UN9Alpha-ketoglutarate-dependent dioxygenase FTO / 0.761
1jsz NDMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2.1.1.57 0.744
2g1m 4HGEgl nine homolog 1 / 0.740
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.718
4bqy FNTEgl nine homolog 1 / 0.714
1c3x 8IGPurine nucleoside phosphorylase 2.4.2.1 0.660
2ofi ADK3-methyladenine DNA glycosylase I / 0.660
4fhb FOLDihydrofolate reductase 1.5.1.3 0.660
3zzh NLGProtein ARG5,6, mitochondrial 2.7.2.8 0.659
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.657
4nhy PD2Prolyl 3-hydroxylase OGFOD1 1.14.11 0.657
1nq0 4HYThyroid hormone receptor beta / 0.655
3dfr MTXDihydrofolate reductase 1.5.1.3 0.655
1khz ADVADP-ribose pyrophosphatase 3.6.1.13 0.654
1toj HCIAspartate aminotransferase 2.6.1.1 0.654
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.654
1i7c MGBS-adenosylmethionine decarboxylase proenzyme 4.1.1.50 0.652
1ohk COPDihydrofolate reductase 1.5.1.3 0.652
3fvu IACKynurenine--oxoglutarate transaminase 1 2.6.1.7 0.652
1dyi FOLDihydrofolate reductase 1.5.1.3 0.651
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.651