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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ie0 PD2 Alpha-ketoglutarate-dependent dioxygenase FTO

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.893
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.718
4ie6 UN9Alpha-ketoglutarate-dependent dioxygenase FTO / 0.700
4i13 FOLDihydrofolate reductase 1.5.1.3 0.672
4p68 MTXDihydrofolate reductase / 0.672
4r29 SAMUncharacterized protein / 0.672
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.671
3t7s SAMUncharacterized protein / 0.670
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.670
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.669
2p1o NLAProtein TRANSPORT INHIBITOR RESPONSE 1 / 0.669
3fri SAH16S rRNA methylase / 0.668
3sxj SAMPutative methyltransferase / 0.668
4j36 1HRKynurenine 3-monooxygenase / 0.667
4ph9 IBPProstaglandin G/H synthase 2 1.14.99.1 0.667
3t0i SAHPutative methyltransferase / 0.666
2g1m 4HGEgl nine homolog 1 / 0.664
4nhy PD2Prolyl 3-hydroxylase OGFOD1 1.14.11 0.663
4ubs DIFPentalenic acid synthase 1.14.15.11 0.661
1khz ADVADP-ribose pyrophosphatase 3.6.1.13 0.658
3wix LC3Induced myeloid leukemia cell differentiation protein Mcl-1 / 0.658
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.656
1s0j MUSTrans-sialidase / 0.656
4aos NAPSteroid monooxygenase / 0.656
4x5i FOLDihydrofolate reductase 1.5.1.3 0.655
2qs3 UBEGlutamate receptor ionotropic, kainate 1 / 0.654
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.654
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.654
1hbm SHTMethyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.653
1hbm SHTMethyl-coenzyme M reductase I subunit beta 2.8.4.1 0.653
1ht8 34CProstaglandin G/H synthase 1 1.14.99.1 0.652