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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ib3 ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.040
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.899
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.892
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.886
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.875
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.867
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.864
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.863
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.860
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.859
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.857
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.854
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.853
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.850
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.842
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.837
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.835
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.832
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.826
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.825
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.818
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.817
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.814
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.794
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.790
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.790
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.786
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.779
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.776
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.772
4ysj ADPCalmodulin-like domain protein kinase / 0.770
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.750
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.746
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.735
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.734
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.734
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.732
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.729
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.729
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.727
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.724
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.718
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.715
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.710
5dn3 ATPAurora kinase A 2.7.11.1 0.708
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.701
3rv4 ADPBiotin carboxylase 6.3.4.14 0.698
4dee ADPAurora kinase A 2.7.11.1 0.697
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.694
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
5dt3 ATPAurora kinase A 2.7.11.1 0.693
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.692
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.692
5dr2 ATPAurora kinase A 2.7.11.1 0.692
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.691
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.690
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.690
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.687
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.687
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.685
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.684
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.684
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.684
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.683
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.682
2pml ANPUncharacterized protein / 0.682
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.682
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.682
2vqd AP2Biotin carboxylase 6.3.4.14 0.681
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.681
4utd ACPAurora kinase A 2.7.11.1 0.680
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.679
2wqe ADPAurora kinase A 2.7.11.1 0.679
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.677
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.677
3ort AGSSerine/threonine protein kinase / 0.677
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.677
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.676
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.675
2zdg ADPD-alanine--D-alanine ligase / 0.675
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.675
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.673
1mq4 ADPAurora kinase A 2.7.11.1 0.671
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.671
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.670
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.669
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.668
5dnr ATPAurora kinase A 2.7.11.1 0.668
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.666
1pk8 ATPSynapsin-1 / 0.665
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.665
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.665
1ir3 ANPInsulin receptor 2.7.10.1 0.663
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.663
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.662
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.661
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.661
3nie ANPMitogen-activated protein kinase / 0.659
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.659
5l8l ADPAurora kinase A 2.7.11.1 0.659
1nj6 A5AProline--tRNA ligase / 0.658
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.658
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.658
4o0u ADNAurora kinase A 2.7.11.1 0.658
1mjh ATPUniversal stress protein MJ0577 / 0.657
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.657
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
4r1l ADPPhenylacetate-coenzyme A ligase / 0.657
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.656
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
4ceg ADPAurora kinase A 2.7.11.1 0.656
4cnf MTASpoU rRNA methylase / 0.656
3orm AGSSerine/threonine protein kinase / 0.655
4bn1 ADPAurora kinase A 2.7.11.1 0.655
4cng SAHSpoU rRNA methylase / 0.655
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.655
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.655
1ol6 ATPAurora kinase A 2.7.11.1 0.654
2dwb ANPAurora kinase A 2.7.11.1 0.654
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.654
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.654
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.654
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.654
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.654
3cly ACPFibroblast growth factor receptor 2 / 0.653
3ork AGSSerine/threonine protein kinase / 0.653
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
4o1p ANPRibonuclease L / 0.653
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.653
4s26 SAHPhosphomethylpyrimidine synthase, chloroplastic 4.1.99.17 0.652
5drd ATPAurora kinase A 2.7.11.1 0.652
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.651
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.650