Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iaz ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.957
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.924
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.919
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.909
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.904
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.876
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.873
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.861
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.858
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.857
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.856
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.856
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.853
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.844
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.844
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.837
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.832
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.827
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.824
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.811
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.800
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.793
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.788
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.785
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.783
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.782
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.779
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.774
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.770
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.768
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.767
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.764
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.764
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.763
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.758
3c50 ADPRhodopsin kinase / 0.758
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
4ysj ADPCalmodulin-like domain protein kinase / 0.756
5dr2 ATPAurora kinase A 2.7.11.1 0.754
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.751
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.750
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.750
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.748
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.747
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.745
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.745
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.744
4utd ACPAurora kinase A 2.7.11.1 0.744
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.740
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.740
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.739
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.739
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.738
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.737
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.736
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.735
5dn3 ATPAurora kinase A 2.7.11.1 0.735
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.734
5dt3 ATPAurora kinase A 2.7.11.1 0.734
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.729
3qc9 ADPRhodopsin kinase / 0.729
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.728
3t8o ATPRhodopsin kinase / 0.727
1ol6 ATPAurora kinase A 2.7.11.1 0.726
2pul ACPMethylthioribose kinase 2.7.1.100 0.726
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.726
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.725
2dwb ANPAurora kinase A 2.7.11.1 0.725
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.725
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.724
2zdg ADPD-alanine--D-alanine ligase / 0.724
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
2olc ADPMethylthioribose kinase 2.7.1.100 0.722
2pui ADPMethylthioribose kinase 2.7.1.100 0.722
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.719
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.719
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.718
5dos ATPAurora kinase A 2.7.11.1 0.718
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.717
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.717
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.716
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.716
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.716
4qny ANPMitogen activated protein kinase, putative / 0.716
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.715
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.714
5dnr ATPAurora kinase A 2.7.11.1 0.714
2pup ADPMethylthioribose kinase 2.7.1.100 0.712
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.712
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.712
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.709
5drd ATPAurora kinase A 2.7.11.1 0.709
3c4z ADPRhodopsin kinase / 0.708
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.708
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.705
2vqd AP2Biotin carboxylase 6.3.4.14 0.702
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.702
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.701
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.701
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.701
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.700
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.698
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.696
3q5i ANPProtein kinase, putative / 0.696
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.695
4dee ADPAurora kinase A 2.7.11.1 0.694
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.693
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.692
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.692
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.692
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.691
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.691
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
5eg3 ACPFibroblast growth factor receptor 2 / 0.690
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.689
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.689
2pun ACPMethylthioribose kinase 2.7.1.100 0.688
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.688
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
1ol5 ADPAurora kinase A 2.7.11.1 0.686
3orl AGSSerine/threonine protein kinase / 0.686
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.686
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.685
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.685
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.685
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.685
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.684
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.684
3nie ANPMitogen-activated protein kinase / 0.682
4bn1 ADPAurora kinase A 2.7.11.1 0.682
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.680
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.680
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.680
4xlv ACPInsulin receptor 2.7.10.1 0.680
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.679
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.678
2py3 ACPFibroblast growth factor receptor 2 / 0.678
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.678
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.677
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.675
3c4w ATPRhodopsin kinase / 0.675
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.675
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.675
5ckw ANPUncharacterized protein / 0.675
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.674
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.674
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.674
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.674
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5iqf GDPBifunctional AAC/APH 2.3.1 0.674
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.673
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.673
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
5iqh GNPBifunctional AAC/APH 2.3.1 0.673
1mq4 ADPAurora kinase A 2.7.11.1 0.672
4c3r ACPAurora kinase A 2.7.11.1 0.672
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.671
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.671
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.671
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.670
1ir3 ANPInsulin receptor 2.7.10.1 0.669
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
3rv4 ADPBiotin carboxylase 6.3.4.14 0.669
1pk8 ATPSynapsin-1 / 0.668
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.668
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.668
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.667
1cm8 ANPMitogen-activated protein kinase 12 / 0.666
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.665
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.665
3ork AGSSerine/threonine protein kinase / 0.664
4ceg ADPAurora kinase A 2.7.11.1 0.664
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.664
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.663
4o1p ANPRibonuclease L / 0.663
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
2wqe ADPAurora kinase A 2.7.11.1 0.661
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.661
1ol7 ADPAurora kinase A 2.7.11.1 0.660
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.660
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.660
5c93 ACPTwo-component system histidine protein kinase / 0.660
5l8j ADPAurora kinase A 2.7.11.1 0.660
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.659
3ori AGSSerine/threonine protein kinase / 0.659
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.659
3orm AGSSerine/threonine protein kinase / 0.658
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3c4x ATPRhodopsin kinase / 0.657
1i44 ACPInsulin receptor 2.7.10.1 0.656
1q3h ANPCystic fibrosis transmembrane conductance regulator / 0.656
3a8w ATPProtein kinase C iota type 2.7.11.13 0.656
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
5iqb GNPBifunctional AAC/APH 2.3.1 0.656
5iqi GNPBifunctional AAC/APH 2.3.1 0.656
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
2pz5 ACPFibroblast growth factor receptor 2 / 0.655
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.655
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.654
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.654
4c3p ACPAurora kinase A 2.7.11.1 0.654
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.654
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.654
3orp AGSSerine/threonine protein kinase / 0.653
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.653
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.653
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.652
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.651
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.651
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.651
4ork GDPBifunctional AAC/APH 2.3.1 0.651
1wbp ADPSRSF protein kinase 1 2.7.11.1 0.650
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.650