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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iao APR NAD-dependent histone deacetylase SIR2 3.5.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iao APRNAD-dependent histone deacetylase SIR2 3.5.1 0.989
5d7q AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.816
5d7p AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.803
3zg6 APRNAD-dependent protein deacetylase sirtuin-6 3.5.1 0.802
5d7o AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.779
2h59 3ODNAD-dependent protein deacetylase / 0.763
4bvh AR6NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3.5.1 0.749
1m2h APRNAD-dependent protein deacylase 1 / 0.708
1m2j APRNAD-dependent protein deacylase 1 / 0.707
1m2k APRNAD-dependent protein deacylase 1 / 0.706
2h59 APRNAD-dependent protein deacetylase / 0.694
2b4y APRNAD-dependent protein deacylase sirtuin-5, mitochondrial / 0.691
1yc2 APRNAD-dependent protein deacylase 2 / 0.688
1m2g APRNAD-dependent protein deacylase 1 / 0.682
4bvb AR6NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3.5.1 0.679
1s7g APRNAD-dependent protein deacylase 2 / 0.654