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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iak ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.987
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.940
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.924
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.920
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.919
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.919
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.914
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.911
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.905
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.902
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.897
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.897
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.894
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.885
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.885
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.884
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.881
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.879
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.871
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.867
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.865
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.862
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.855
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.825
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.823
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.812
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.810
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.794
4ysj ADPCalmodulin-like domain protein kinase / 0.791
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.787
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.785
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.784
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.784
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.783
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.782
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.779
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.779
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.776
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.776
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.775
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.769
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.767
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.766
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.764
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.762
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.761
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.760
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.759
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.757
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.756
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.756
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
2pml ANPUncharacterized protein / 0.753
5dt3 ATPAurora kinase A 2.7.11.1 0.753
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.752
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.750
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.749
5dn3 ATPAurora kinase A 2.7.11.1 0.749
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.746
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
3rv4 ADPBiotin carboxylase 6.3.4.14 0.745
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.744
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.744
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.739
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.737
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.737
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.737
2olc ADPMethylthioribose kinase 2.7.1.100 0.736
4utd ACPAurora kinase A 2.7.11.1 0.735
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.733
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.733
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.731
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.730
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.730
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.727
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.724
4dee ADPAurora kinase A 2.7.11.1 0.723
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.723
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.723
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.722
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.721
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.718
4qny ANPMitogen activated protein kinase, putative / 0.718
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.716
5dr2 ATPAurora kinase A 2.7.11.1 0.716
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.715
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.715
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.714
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.713
1ol6 ATPAurora kinase A 2.7.11.1 0.712
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.712
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.712
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.711
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.710
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.707
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.707
2vqd AP2Biotin carboxylase 6.3.4.14 0.705
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.705
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.705
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.704
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.703
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.702
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.700
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.699
3nie ANPMitogen-activated protein kinase / 0.698
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.698
5eg3 ACPFibroblast growth factor receptor 2 / 0.698
2zdg ADPD-alanine--D-alanine ligase / 0.697
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.696
5dnr ATPAurora kinase A 2.7.11.1 0.696
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.695
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.695
2pui ADPMethylthioribose kinase 2.7.1.100 0.694
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.694
1ol5 ADPAurora kinase A 2.7.11.1 0.692
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.692
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.691
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.691
2dwb ANPAurora kinase A 2.7.11.1 0.690
3c4z ADPRhodopsin kinase / 0.690
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.689
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.689
5dt4 ATPAurora kinase A 2.7.11.1 0.689
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.687
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
5iqh GNPBifunctional AAC/APH 2.3.1 0.687
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.686
4xlv ACPInsulin receptor 2.7.10.1 0.686
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.685
4bn1 ADPAurora kinase A 2.7.11.1 0.685
5dos ATPAurora kinase A 2.7.11.1 0.685
2pul ACPMethylthioribose kinase 2.7.1.100 0.684
2fsn ADPArchaeal actin homolog / 0.683
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.682
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.682
2pup ADPMethylthioribose kinase 2.7.1.100 0.681
2pyw ADPMethylthioribose kinase 2.7.1.100 0.681
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.680
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.680
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.680
1u54 ACPActivated CDC42 kinase 1 / 0.679
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.679
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.679
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.679
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.679
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.679
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.678
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.678
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.678
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.677
2pzp ACPFibroblast growth factor receptor 2 / 0.676
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.676
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.676
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.675
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.674
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
5ckw ANPUncharacterized protein / 0.674
5drd ATPAurora kinase A 2.7.11.1 0.674
1mq4 ADPAurora kinase A 2.7.11.1 0.673
2pun ACPMethylthioribose kinase 2.7.1.100 0.673
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.673
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.673
3t8o ATPRhodopsin kinase / 0.673
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.673
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5iqf GDPBifunctional AAC/APH 2.3.1 0.673
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4fu0 ADPD-alanine--D-alanine ligase / 0.672
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.671
2py3 ACPFibroblast growth factor receptor 2 / 0.671
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.670
4o4f ATPKinase / 0.669
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.669
1ol7 ADPAurora kinase A 2.7.11.1 0.668
4c3r ACPAurora kinase A 2.7.11.1 0.668
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.667
3cly ACPFibroblast growth factor receptor 2 / 0.667
4mv8 ACPBiotin carboxylase 6.3.4.14 0.667
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.665
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.665
4u0o MTALipoyl synthase 2 / 0.665
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.664
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.664
3orm AGSSerine/threonine protein kinase / 0.663
4o1p ANPRibonuclease L / 0.663
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
3qc9 ADPRhodopsin kinase / 0.662
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
3ori AGSSerine/threonine protein kinase / 0.661
1q3h ANPCystic fibrosis transmembrane conductance regulator / 0.660
2wqe ADPAurora kinase A 2.7.11.1 0.660
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.660
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.659
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.659
1cm8 ANPMitogen-activated protein kinase 12 / 0.658
3orl AGSSerine/threonine protein kinase / 0.658
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.658
3c50 ADPRhodopsin kinase / 0.657
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.657
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.656
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.656
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.655
3bu5 ATPInsulin receptor 2.7.10.1 0.655
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.655
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.654
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.654
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.654
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.653
1i44 ACPInsulin receptor 2.7.10.1 0.652
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.652
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.652
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.652
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.652
3wo0 ADPAlanine--anticapsin ligase / 0.652
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4xeo A5AAlanine--tRNA ligase, cytoplasmic / 0.651
3tw6 ADPPyruvate carboxylase / 0.650
4j98 ACPFibroblast growth factor receptor 2 / 0.650
4kpu FADElectron transfer flavoprotein alpha/beta-subunit / 0.650