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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i5h G17 Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 1.301
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.841
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.831
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.777
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.755
3d83 GK6Mitogen-activated protein kinase 14 / 0.748
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.746
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.739
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.733
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.729
3vnt 0JAVascular endothelial growth factor receptor 2 2.7.10.1 0.728
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.722
3bv3 P39Mitogen-activated protein kinase 14 / 0.715
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.715
2zb1 GK4Mitogen-activated protein kinase 14 / 0.712
3e92 G6AMitogen-activated protein kinase 14 / 0.711
2p4i MR9Angiopoietin-1 receptor 2.7.10.1 0.706
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.700
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.685
3rin I2OMitogen-activated protein kinase 14 / 0.681
2bak AQZMitogen-activated protein kinase 14 / 0.676
4a9y AQZMitogen-activated protein kinase 14 / 0.676
2rg5 279Mitogen-activated protein kinase 14 / 0.672
3ds6 A17Mitogen-activated protein kinase 14 / 0.668
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.667
1wbt WBTMitogen-activated protein kinase 14 / 0.665
1wbs LI2Mitogen-activated protein kinase 14 / 0.664
3bv2 P38Mitogen-activated protein kinase 14 / 0.664
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.660
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.656
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.656
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.652
3vo3 0KFVascular endothelial growth factor receptor 2 2.7.10.1 0.651
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.651