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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hyu 1BK Mitogen-activated protein kinase 8 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hyu 1BKMitogen-activated protein kinase 8 2.7.11.24 1.038
4izy 1J2Mitogen-activated protein kinase 8 2.7.11.24 0.957
4hys 1BJMitogen-activated protein kinase 8 2.7.11.24 0.835
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.686
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.672
3fzr 3JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.662
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.661