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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hlw TES Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hlw TESAndrogen receptor / 1.085
2q7i TESAndrogen receptor / 1.051
1t7r DHTAndrogen receptor / 0.998
4ofr DHTAndrogen receptor / 0.996
2ylp TESAndrogen receptor / 0.995
1t76 DHTAndrogen receptor / 0.991
2q7k TESAndrogen receptor / 0.991
1t79 DHTAndrogen receptor / 0.986
4oea DHTAndrogen receptor / 0.983
1t7f DHTAndrogen receptor / 0.979
4oey DHTAndrogen receptor / 0.979
1t7m DHTAndrogen receptor / 0.967
2ama DHTAndrogen receptor / 0.967
1t65 DHTAndrogen receptor / 0.961
1t73 DHTAndrogen receptor / 0.956
2ylq TESAndrogen receptor / 0.956
2am9 TESAndrogen receptor / 0.955
1t5z DHTAndrogen receptor / 0.954
2pit DHTAndrogen receptor / 0.951
1t74 DHTAndrogen receptor / 0.948
2pkl DHTAndrogen receptor / 0.936
4oed DHTAndrogen receptor / 0.935
2pio DHTAndrogen receptor / 0.918
2z4j DHTAndrogen receptor / 0.917
2piq DHTAndrogen receptor / 0.905
2pip DHTAndrogen receptor / 0.901
4oez DHTAndrogen receptor / 0.893
2q7j TESAndrogen receptor / 0.860
1xj7 DHTAndrogen receptor / 0.854
1xow R18Androgen receptor / 0.849
2piw DHTAndrogen receptor / 0.848
2pix DHTAndrogen receptor / 0.840
1xq3 R18Androgen receptor / 0.838
2q7l TESAndrogen receptor / 0.806
2ao6 R18Androgen receptor / 0.797
1t7t DHTAndrogen receptor / 0.739
4ofu DHTAndrogen receptor / 0.724
5dx3 ESTEstrogen receptor / 0.723
2piu DHTAndrogen receptor / 0.720
1gs4 ZK5Androgen receptor / 0.707
1t63 DHTAndrogen receptor / 0.707
1gwr ESTEstrogen receptor / 0.700
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.698
2j7x ESTEstrogen receptor beta / 0.692
2piv DHTAndrogen receptor / 0.691
1lhu ESTSex hormone-binding globulin / 0.690
2aax PDNMineralocorticoid receptor / 0.677
4e5l DBHPolymerase acidic protein / 0.676
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.675
4q0a 4OAVitamin D3 receptor A / 0.674
3up0 D7SaceDAF-12 / 0.671
2ylo TESAndrogen receptor / 0.668
2ocf ESTEstrogen receptor / 0.667
2pir DHTAndrogen receptor / 0.667
1lhv NOGSex hormone-binding globulin / 0.666
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.665
3uud ESTEstrogen receptor / 0.665
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.662
2aa2 AS4Mineralocorticoid receptor / 0.662
4pxm ESTEstrogen receptor / 0.661
1n83 CLRNuclear receptor ROR-alpha / 0.659
3zqt TESAndrogen receptor / 0.659
5dxg ESTEstrogen receptor / 0.659
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.658
2w8y 486Progesterone receptor / 0.655
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.655
4k7a DHTAndrogen receptor / 0.655
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.654
4qe6 JN3Bile acid receptor / 0.654
2aa6 STRMineralocorticoid receptor / 0.653
3ols ESTEstrogen receptor beta / 0.653
1y9r 1CAMineralocorticoid receptor / 0.652
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.652
2pnu ENMAndrogen receptor / 0.650
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.650
3w5p 4OAVitamin D3 receptor / 0.650