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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hdb G52 Gag-Pol polyprotein 3.4.23.16

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4hdb G52Gag-Pol polyprotein 3.4.23.16 1.360
2z4o 065Gag-Pol polyprotein 3.4.23.16 1.251
3qaa G04Gag-Pol polyprotein 3.4.23.16 1.244
2qci 065Gag-Pol polyprotein 3.4.23.16 1.236
3ok9 G52Gag-Pol polyprotein 3.4.23.16 1.232
4heg G52Gag-Pol polyprotein 3.4.23.16 1.216
2qd6 065Gag-Pol polyprotein 3.4.23.16 1.189
2qd8 065Gag-Pol polyprotein 3.4.23.16 1.166
4kb9 G79Protease / 1.155
4hdp G52Gag-Pol polyprotein 3.4.23.16 1.133
4dfg 0JVGag-Pol polyprotein 3.4.23.16 1.123
3vfa 031Gag-Pol polyprotein 3.4.23.16 1.114
2f80 017Gag-Pol polyprotein 3.4.23.16 1.100
3o9a K14Pol polyprotein / 1.098
4hdf G52Gag-Pol polyprotein 3.4.23.16 1.088
3ecg 065Gag-Pol polyprotein 3.4.23.47 1.087
3o9h K2EGag-Pol polyprotein / 1.065
3o9c K20Pol polyprotein / 1.055
4ye3 G04Gag-Pol polyprotein 3.4.23.16 1.050
3st5 G89Gag-Pol polyprotein 3.4.23.16 1.046
3pwm 017Gag-Pol polyprotein 3.4.23.16 1.044
4dqb 017Gag-Pol polyprotein / 1.044
4dqe 017Gag-Pol polyprotein / 1.041
3djk G55Gag-Pol polyprotein 3.4.23.16 1.030
3d20 017Gag-Pol polyprotein 3.4.23.16 1.028
2i4u DJRProtease / 1.017
2ieo 017Protease / 1.016
3cyw 017Gag-Pol polyprotein 3.4.23.16 1.011
3sab F78Protease / 1.007
2f81 017Gag-Pol polyprotein 3.4.23.16 1.004
3d1z 017Gag-Pol polyprotein 3.4.23.16 1.004
3o9g F53Gag-Pol polyprotein / 1.003
3vf7 031Gag-Pol polyprotein 3.4.23.16 0.999
3dk1 G05Gag-Pol polyprotein 3.4.23.16 0.998
3o9b K2APol polyprotein / 0.997
3vf5 031Gag-Pol polyprotein 3.4.23.16 0.994
4njs G08Protease / 0.994
3o9e A60Pol polyprotein / 0.989
1t3r 017Gag-Pol polyprotein 3.4.23.16 0.987
3o9f K2DGag-Pol polyprotein / 0.987
3r4b 74TGag-Pol polyprotein / 0.987
2i4x KGQProtease / 0.980
3bvb 017Gag-Pol polyprotein 3.4.23.16 0.980
2i4w KGQProtease / 0.976
2fdd 385Pol protein / 0.974
3jvy 017Gag-Pol polyprotein 3.4.23.16 0.974
3sa9 A68Protease / 0.974
3lzs 017Gag-Pol polyprotein 3.4.23.16 0.972
2qd7 065Gag-Pol polyprotein 3.4.23.16 0.968
4dqc 017Gag-Pol polyprotein / 0.968
3s54 017Protease / 0.961
4djq M86Pol polyprotein / 0.960
2hb3 GRLProtease / 0.959
1t7i 017Gag-Pol polyprotein 3.4.23.16 0.955
2hs2 017Protease / 0.955
3mws 017Pol protein / 0.952
4dqf 017Gag-Pol polyprotein / 0.952
3ucb 017Gag-Pol polyprotein / 0.950
4j54 G52Gag-Pol polyprotein 3.4.23.16 0.945
3ggu 017Gag-Pol polyprotein 3.4.23.16 0.941
3em3 478Gag-Pol polyprotein 3.4.23.16 0.933
4njt 017Protease / 0.927
3ec0 GRLGag-Pol polyprotein 3.4.23.47 0.926
4djo MK5Pol polyprotein / 0.925
4i8z G08Gag-Pol polyprotein 3.4.23.16 0.925
3oxw 017Gag-Pol polyprotein 3.4.23.16 0.924
2idw 017Protease / 0.923
2ien 017Gag-Pol polyprotein 3.4.23.16 0.922
4q1y 017Gag-Pol polyprotein 3.4.23.16 0.918
3o9i A61Gag-Pol polyprotein / 0.917
2hs1 017Protease / 0.910
3i6o GR6Gag-Pol polyprotein 3.4.23.16 0.910
3i7e DJRGag-Pol polyprotein / 0.909
3sa5 A69Protease / 0.909
3nu6 478Gag-Pol polyprotein 3.4.23.16 0.906
3lzv 017Gag-Pol polyprotein 3.4.23.16 0.905
3ekv 478Gag-Pol polyprotein 3.4.23.16 0.902
3nu9 478Gag-Pol polyprotein 3.4.23.16 0.902
3o9d K19Pol polyprotein / 0.900
3oxv 478Gag-Pol polyprotein 3.4.23.16 0.899
3em6 017Gag-Pol polyprotein 3.4.23.16 0.898
2i4d QFIProtease / 0.896
4q1x 017Gag-Pol polyprotein 3.4.23.16 0.894
2f8g 017Gag-Pol polyprotein 3.4.23.16 0.893
3nu5 478Gag-Pol polyprotein 3.4.23.16 0.893
3oy4 017Gag-Pol polyprotein 3.4.23.16 0.893
4dqh 017Gag-Pol polyprotein / 0.891
3nu3 478Gag-Pol polyprotein 3.4.23.16 0.890
3ekt 017Gag-Pol polyprotein 3.4.23.16 0.889
3sa8 K83Protease / 0.889
2i4v DJRV-1 protease / 0.888
2i0a MUIProtease / 0.883
2qi5 MZ7Gag-Pol polyprotein / 0.882
2qhy MZ1Gag-Pol polyprotein / 0.881
3nuj 478Gag-Pol polyprotein 3.4.23.16 0.875
4j55 031Gag-Pol polyprotein 3.4.23.16 0.875
3oxx DR7Gag-Pol polyprotein 3.4.23.16 0.874
4djp M73Pol polyprotein / 0.873
4q1w 017Gag-Pol polyprotein 3.4.23.16 0.872
3gi4 K60Gag-Pol polyprotein / 0.871
3gi5 K62Gag-Pol polyprotein / 0.871
2qi7 MZ9Gag-Pol polyprotein / 0.869
3gi6 D78Gag-Pol polyprotein / 0.866
3vfb 031Gag-Pol polyprotein 3.4.23.16 0.866
4rvj 478Protease / 0.866
3o99 K13Pol polyprotein / 0.864
3t3c 017Gag-Pol polyprotein 3.4.23.16 0.850
2i0d MUTProtease / 0.849
3sa7 55AProtease / 0.847
3mxe K54Gag-Pol polyprotein 3.4.23.16 0.846
3nuo 478Gag-Pol polyprotein 3.4.23.16 0.846
3lzu 017Gag-Pol polyprotein 3.4.23.16 0.844
2qi6 MZ8Gag-Pol polyprotein / 0.838
2psu MUUProtease / 0.836
3jw2 017Gag-Pol polyprotein 3.4.23.16 0.833
3s43 478Protease / 0.833
1xl5 190Gag-Pol polyprotein 3.4.23.16 0.830
2qi0 MZ3Gag-Pol polyprotein / 0.829
2qhz MZ2Gag-Pol polyprotein / 0.827
2qi4 MZ6Gag-Pol polyprotein / 0.824
3eky DR7Gag-Pol polyprotein 3.4.23.16 0.820
3mxd K53Gag-Pol polyprotein 3.4.23.16 0.820
1z1h HBBGag-Pol polyprotein 3.4.23.16 0.819
4hla 017Gag-Pol polyprotein 3.4.23.16 0.818
3ttp 017Gag-Pol polyprotein 3.4.23.16 0.816
2qi3 MZ5Gag-Pol polyprotein / 0.815
3nu4 478Gag-Pol polyprotein 3.4.23.16 0.815
2fde 385Gag-Pol polyprotein 3.4.23.16 0.813
1d4l PI9Gag-Pol polyprotein 3.4.23.16 0.812
3saa 77FProtease / 0.812
3sa4 F72Protease / 0.809
3sa3 23XProtease / 0.798
2cem 2AHPol protein / 0.789
3em4 DR7Gag-Pol polyprotein 3.4.23.16 0.788
4djr 0KJPol polyprotein / 0.781
2wkz 5AHGag-Pol polyprotein / 0.777
3k4v ROCGag-Pol polyprotein 3.4.23.16 0.777
1z1r HBHGag-Pol polyprotein 3.4.23.16 0.775
4k4p 3TLGag-Pol polyprotein / 0.770
3sm2 478Putative gag-pro-pol polyprotein / 0.769
3a2o KNJGag-Pol polyprotein 3.4.23.16 0.767
4j5j 478Gag-Pol polyprotein 3.4.23.16 0.765
1d4j MSCGag-Pol polyprotein 3.4.23.16 0.762
2avm 2NCGag-Pol polyprotein 3.4.23.16 0.761
2bbb HH1Gag-Pol polyprotein 3.4.23.16 0.759
2pk6 O33V-1 protease / 0.759
1w5x BE5Gag-Pol polyprotein 3.4.23.16 0.757
2fxe DR7Gag-Pol polyprotein 3.4.23.16 0.757
1t7j 478Gag-Pol polyprotein 3.4.23.16 0.756
3sa6 F71Protease / 0.756
3dcr KVSProtease / 0.755
2aqu DR7Gag-Pol polyprotein 3.4.23.16 0.754
1w5w BE4Gag-Pol polyprotein 3.4.23.16 0.753
3el9 DR7Gag-Pol polyprotein 3.4.23.16 0.753
2psv MUVProtease / 0.750
1m0b 0ZQGag-Pol polyprotein 3.4.23.16 0.749
3d1y ROCGag-Pol polyprotein 3.4.23.16 0.748
3nyg 2NCGag-Pol polyprotein 3.4.23.16 0.748
3kdb 006Gag-Pol polyprotein 3.4.23.16 0.747
2q54 MU1Protease / 0.746
2qak 1UNGag-Pol polyprotein 3.4.23.16 0.746
1d4h BEHGag-Pol polyprotein 3.4.23.16 0.745
2nmy ROCProtease / 0.745
1mrw K57Gag-Pol polyprotein 3.4.23.16 0.744
2aoe 0Q4Gag-Pol polyprotein 3.4.23.16 0.741
1mtr PI6Gag-Pol polyprotein 3.4.23.16 0.740
1b6k PI5Gag-Pol polyprotein 3.4.23.16 0.739
1fej 2NCGag-Pol polyprotein 3.4.23.16 0.739
2f3k RO1Protease / 0.738
1ec0 BEDGag-Pol polyprotein 3.4.23.16 0.736
1w5y BE6Gag-Pol polyprotein 3.4.23.16 0.736
1mrx K57Gag-Pol polyprotein 3.4.23.16 0.735
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.734
1ffi 2NCGag-Pol polyprotein 3.4.23.16 0.734
3nxe 2NCProtease / 0.734
1ajv NMBGag-Pol polyprotein 3.4.23.16 0.733
1ida 0POGag-Pol polyprotein 3.4.23.47 0.732
2q5k AB1Protease / 0.732
2rkf AB1Pol protein / 0.732
2pym 1UNGag-Pol polyprotein 3.4.23.16 0.731
1zsf 0ZSGag-Pol polyprotein 3.4.23.16 0.730
2bb9 AKCGag-Pol polyprotein 3.4.23.16 0.730
3hzc 2NCProtease / 0.730
3cyx ROCGag-Pol polyprotein 3.4.23.16 0.729
1msm JE2Gag-Pol polyprotein 3.4.23.16 0.726
2fle AIProtease / 0.725
3nwq 2NCGag-Pol polyprotein 3.4.23.16 0.725
2q63 1UNGag-Pol polyprotein 3.4.23.16 0.724
1izh Q50Protease / 0.722
2cen 4AHProtease / 0.722
3sac AF8Protease / 0.720
1ebz BECGag-Pol polyprotein 3.4.23.16 0.719
1hxw RITGag-Pol polyprotein / 0.716
3d1x ROCGag-Pol polyprotein 3.4.23.16 0.716
9hvp 0E9Gag-Pol polyprotein / 0.714
3tl9 ROCGag-Pol polyprotein 3.4.23.16 0.713
2p3a 3TLPol protein / 0.712
1bdr IM1Gag-Pol polyprotein 3.4.23.16 0.711
3s56 ROCProtease / 0.711
1npa 3NHGag-Pol polyprotein 3.4.23.16 0.710
1npw LGZGag-Pol polyprotein 3.4.23.16 0.710
1ff0 2NCGag-Pol polyprotein 3.4.23.16 0.709
1sdv MK1Gag-Pol polyprotein 3.4.23.16 0.709
3ekw DR7Gag-Pol polyprotein 3.4.23.16 0.707
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.706
3bxr DRRGag-Pol polyprotein 3.4.23.16 0.705
2a1e IPFGag-Pol polyprotein 3.4.23.16 0.704
1fg6 2NCGag-Pol polyprotein 3.4.23.16 0.703
1mer DMQGag-Pol polyprotein 3.4.23.16 0.703
1yt9 OISGag-Pol polyprotein / 0.701
2p3c 3TLProtease / 0.701
2qhc AB1Protease / 0.701
3el1 DR7Gag-Pol polyprotein 3.4.23.16 0.701
2pk5 075Protease / 0.700
3so9 017Pol protein / 0.699
1sdt MK1Gag-Pol polyprotein 3.4.23.16 0.697
1siv PSIGag-Pol polyprotein / 0.697
1wbm BLLPol protein / 0.695
2wl0 5AHGag-Pol polyprotein / 0.695
3i2l 2NCProtease / 0.695
3pwr ROCGag-Pol polyprotein 3.4.23.16 0.694
1k6t XN1Gag-Pol polyprotein 3.4.23.16 0.692
2qi1 MZ4Gag-Pol polyprotein / 0.692
3kfr 3TLGag-Pol polyprotein / 0.691
1hpx KNIGag-Pol polyprotein / 0.690
1fff 0Q4Gag-Pol polyprotein 3.4.23.16 0.689
1fg8 0Q4Gag-Pol polyprotein 3.4.23.16 0.689
1k2c 0Q4Gag-Pol polyprotein 3.4.23.16 0.689
1a8g 2Z4Gag-Pol polyprotein 3.4.23.16 0.686
3kdc JZPGag-Pol polyprotein 3.4.23.16 0.686
1mui AB1Protease / 0.685
2rkg AB1Pol protein / 0.685
3slz 3TLPutative gag-pro-pol polyprotein / 0.685
1zsr 0ZTGag-Pol polyprotein 3.4.23.16 0.684
1ec2 BEJGag-Pol polyprotein 3.4.23.16 0.682
1hvk A79Gag-Pol polyprotein / 0.682
3ekp 478Gag-Pol polyprotein 3.4.23.16 0.682
1hpv 478Gag-Pol polyprotein / 0.681
2nnk ROCProtease / 0.681
2pwr G4GGag-Pol polyprotein 3.4.23.16 0.681
2bpy 3INGag-Pol polyprotein 3.4.23.16 0.679
1d4i BEGGag-Pol polyprotein 3.4.23.16 0.675
2o4p TPVProtease / 0.675
2uxz HI1Gag-Pol polyprotein 3.4.23.16 0.675
2fxd DR7Pol polyprotein / 0.674
2xyf G40Gag-Pol polyprotein / 0.674
1fgc 2NCGag-Pol polyprotein 3.4.23.16 0.673
1mes DMPGag-Pol polyprotein 3.4.23.16 0.672
2avs MK1Gag-Pol polyprotein 3.4.23.16 0.671
2xye CXGGag-Pol polyprotein / 0.670
1ec3 MS3Gag-Pol polyprotein 3.4.23.16 0.669
2nnp ROCProtease / 0.669
1hwr 216Gag-Pol polyprotein 3.4.23.16 0.668
1k2b 0Q4Gag-Pol polyprotein 3.4.23.16 0.668
2hc0 AB2Protease / 0.667
4a6b QG8Gag-Pol polyprotein 3.4.23.16 0.666
1g2k NM1Gag-Pol polyprotein 3.4.23.16 0.665
2p3b 3TLV-1 PROTEASE protein / 0.665
2p3b 3TLV-1 protease / 0.665
3ndu ROCGag-Pol polyprotein 3.4.23.16 0.665
1hvi A77Protease / 0.664
1npv L27Gag-Pol polyprotein 3.4.23.16 0.664
1ohr 1UNV-1 PROTEASE protein / 0.664
1wbk 568Pol protein / 0.664
2b60 RITPol polyprotein / 0.664
1t7k BH0Gag-Pol polyprotein 3.4.23.16 0.663
2bqv A1AProtease / 0.663
1bwb 146Gag-Pol polyprotein 3.4.23.16 0.661
2bpz 3INGag-Pol polyprotein 3.4.23.16 0.661
3qp0 NI8Gag-Pol polyprotein 3.4.23.16 0.661
1dmp DMQGag-Pol polyprotein 3.4.23.16 0.659
1w5v BE3Gag-Pol polyprotein 3.4.23.16 0.659
3gga GGWGag-Pol polyprotein / 0.659
1hvj A78Gag-Pol polyprotein / 0.657
3el0 1UNGag-Pol polyprotein 3.4.23.16 0.657
3kfn 3TLGag-Pol polyprotein / 0.657
3ufn ROCGag-Pol polyprotein / 0.657
1a94 0Q4Gag-Pol polyprotein 3.4.23.16 0.655
1hsg MK1Gag-Pol polyprotein / 0.655
3nls 016Gag-Pol polyprotein 3.4.23.16 0.655
2uy0 HV1Gag-Pol polyprotein 3.4.23.16 0.654
1c6x 3INProtease / 0.653
2a4f AAUV-1 protease / 0.652
1sbg IM1Gag-Pol polyprotein / 0.650
2r3w G3GGag-Pol polyprotein 3.4.23.16 0.650