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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h76 10B Macrophage metalloelastase 3.4.24.65

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h76 10BMacrophage metalloelastase 3.4.24.65 1.068
4h49 L29Macrophage metalloelastase 3.4.24.65 0.874
4ja1 NGHStromelysin-1 3.4.24.17 0.791
4dpe NGHStromelysin-1 3.4.24.17 0.781
2w0d CGSMacrophage metalloelastase 3.4.24.65 0.775
3oho Z79Stromelysin-1 3.4.24.17 0.774
3ts4 EEGMacrophage metalloelastase 3.4.24.65 0.760
1g49 111Stromelysin-1 3.4.24.17 0.756
4g9l NGHStromelysin-1 3.4.24.17 0.751
3o2x 3O2Collagenase 3 3.4.24 0.730
1hy7 MBSStromelysin-1 3.4.24.17 0.729
2woa 576Macrophage metalloelastase 3.4.24.65 0.729
2i47 KGYDisintegrin and metalloproteinase domain-containing protein 17 3.4.24.86 0.713
1zs0 EINNeutrophil collagenase 3.4.24.34 0.712
4i03 L88Macrophage metalloelastase 3.4.24.65 0.708
3zxh E41Collagenase 3 3.4.24 0.693
4guy KLJMacrophage metalloelastase 3.4.24.65 0.689
1bzs BSINeutrophil collagenase 3.4.24.34 0.688
2ow0 6MRMatrix metalloproteinase-9 3.4.24.35 0.683
4h1q 0XXMatrix metalloproteinase-9 3.4.24.35 0.672
1bqo N25Stromelysin-1 3.4.24.17 0.666
2d1n FA4Collagenase 3 3.4.24 0.664
2d1o FA4Stromelysin-1 3.4.24.17 0.664
2yig 5ELCollagenase 3 3.4.24 0.663
1hv5 RXPStromelysin-3 3.4.24 0.660
1zxc IH6Disintegrin and metalloproteinase domain-containing protein 17 3.4.24.86 0.650