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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h57 0PJ Thermolysin 3.4.24.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h57 0PJThermolysin 3.4.24.27 1.142
3t8c UBWThermolysin 3.4.24.27 1.064
4d9w X32Thermolysin 3.4.24.27 1.053
3t87 UBZThermolysin 3.4.24.27 1.021
3t8d UBVThermolysin 3.4.24.27 1.007
3t74 UBYThermolysin 3.4.24.27 1.004
3fv4 1U4Thermolysin 3.4.24.27 0.964
3fvp UB2Thermolysin 3.4.24.27 0.937
3t8h UBSThermolysin 3.4.24.27 0.926
4tmn 0PKThermolysin 3.4.24.27 0.909
6tmn 0PIThermolysin 3.4.24.27 0.882
4b52 RDFBacillolysin / 0.861
2tmn 0FAThermolysin 3.4.24.27 0.855
4cth RDFNeprilysin / 0.822
3zuk RDFEndopeptidase, peptidase family M13 / 0.782
4zr5 RDFNeprilysin / 0.777
1u4g HPIElastase 3.4.24.26 0.711
3dwb RDFEndothelin-converting enzyme 1 3.4.24.71 0.710
3f28 S7BThermolysin 3.4.24.27 0.708
3fgd BYAThermolysin 3.4.24.27 0.671
1qf2 TI3Thermolysin 3.4.24.27 0.668
1r1i TI1Neprilysin / 0.667
1r1j OIRNeprilysin / 0.667
4q4e BB2Aminopeptidase N 3.4.11.2 0.655