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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h4s FAD Biphenyl dioxygenase ferredoxin reductase subunit

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.465
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.461
2gr1 FADFerredoxin reductase / 1.455
2yvf FADFerredoxin reductase / 1.411
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.409
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.373
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.356
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.313
2gr3 FADFerredoxin reductase / 1.182
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.180
2gqw FADFerredoxin reductase / 1.162
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.162
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.159
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.158
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.158
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.143
2gr0 FADFerredoxin reductase / 1.118
1d7y FADFerredoxin reductase / 1.106
1f3p FADFerredoxin reductase / 1.077
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.897
1q1r FADPutidaredoxin reductase 1.18.1.5 0.877
2yvj FADFerredoxin reductase / 0.876
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.859
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.855
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.852
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.844
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.833
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.830
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.826
1q1w FADPutidaredoxin reductase 1.18.1.5 0.805
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.794
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.791
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.775
3rha FDAPutrescine oxidase / 0.774
1h83 FADPolyamine oxidase 1.5.3.14 0.769
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.755
3cgb FADCoenzyme A disulfide reductase / 0.754
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.751
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.748
3kpf FADPolyamine oxidase 1.5.3.14 0.744
3ish FADThioredoxin reductase 1.8.1.9 0.743
3t37 FADPyridoxine 4-oxidase / 0.742
3f8r NAPNADH oxidase/thioredoxin reductase / 0.740
3f8d FADNADH oxidase/thioredoxin reductase / 0.739
2yg7 FADPutrescine oxidase / 0.737
2y48 FADLysine-specific histone demethylase 1A 1 0.736
2yg6 FADPutrescine oxidase / 0.735
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.734
3cgc FADCoenzyme A disulfide reductase / 0.734
1rsg FADPolyamine oxidase FMS1 / 0.732
4em3 FADCoenzyme A disulfide reductase / 0.730
2yg3 FADPutrescine oxidase / 0.728
4em4 FADCoenzyme A disulfide reductase / 0.725
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.723
2yg4 FADPutrescine oxidase / 0.722
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.718
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.717
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.716
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.712
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.712
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.711
2iw5 FADLysine-specific histone demethylase 1A 1 0.709
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.709
4xbf FADLysine-specific histone demethylase 1A 1 0.709
1yqz FADCoenzyme A disulfide reductase / 0.706
1z6l FADPolyamine oxidase FMS1 / 0.705
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.705
3r9u FADThioredoxin reductase / 0.703
3ics FADCoenzyme A disulfide reductase / 0.702
4eqw FADCoenzyme A disulfide reductase / 0.702
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.701
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.700
3icr FADCoenzyme A disulfide reductase / 0.700
2cdu FADNADH oxidase / 0.699
2jb1 FADL-amino acid oxidase / 0.699
2q0k FADThioredoxin reductase 1.8.1.9 0.697
4emw FADCoenzyme A disulfide reductase / 0.697
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.696
3cge FADCoenzyme A disulfide reductase / 0.696
2e1m FADL-glutamate oxidase / 0.695
1f8w FADNADH peroxidase 1.11.1.1 0.693
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.688
1tdo FADL-amino-acid oxidase 1.4.3.2 0.684
3k30 ADPHistamine dehydrogenase / 0.682
3syi FADSulfide-quinone reductase / 0.682
4usr FADMonooxygenase / 0.682
2jb2 FADL-amino acid oxidase / 0.679
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.679
1y56 ATPUncharacterized protein / 0.678
1yy5 FADPolyamine oxidase FMS1 / 0.678
4j33 FADKynurenine 3-monooxygenase / 0.678
4u8o FDAUDP-galactopyranose mutase / 0.676
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.675
3fg2 FADPutative rubredoxin reductase / 0.674
4wx1 FDAUDP-galactopyranose mutase / 0.674
3ukf FDAUDP-galactopyranose mutase / 0.673
3we0 FADLysine 2-monooxygenase / 0.673
1joa FADNADH peroxidase 1.11.1.1 0.672
3ihg FADAklavinone 12-hydroxylase RdmE / 0.672
3kkj FADRenalase / 0.671
4ttc FMNIodotyrosine deiodinase 1 / 0.671
2q0l FADThioredoxin reductase 1.8.1.9 0.670
2whd FADThioredoxin reductase / 0.669
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.669
4a5l FADThioredoxin reductase / 0.669
3cgd FADCoenzyme A disulfide reductase / 0.667
3cnt FADPolyamine oxidase FMS1 / 0.667
4cnj FADL-amino acid oxidase / 0.666
1f8s FADL-amino-acid oxidase 1.4.3.2 0.665
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.665
3ad9 FADSubunit beta of sarcosine oxidase / 0.665
3kpk FADSulfide-quinone reductase / 0.665
3qj4 FADRenalase / 0.665
4b69 FADL-ornithine N(5)-monooxygenase / 0.664
1qo8 FADFumarate reductase flavoprotein subunit / 0.663
2fzm FADBifunctional protein PutA 1.5.5.2 0.662
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.662
4u8n FDAUDP-galactopyranose mutase / 0.661
5a89 FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.661
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.660
3ukk FADUDP-galactopyranose mutase / 0.660
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
4h6r FDAProline dehydrogenase / 0.659
5dbj FADFADH2-dependent halogenase PltA / 0.659
1iqr FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.658
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.658
2jae FADL-amino acid oxidase / 0.658
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.658
4la1 FADThioredoxin glutathione reductase / 0.657
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.656
3nlc FADUncharacterized protein / 0.656
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.656
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.656
4gcm FADThioredoxin reductase 1.8.1.9 0.656
4z24 FADPutative GMC-type oxidoreductase R135 1 0.656
1geu FADGlutathione reductase 1.8.1.7 0.655
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.654
3utg FDAUDP-galactopyranose mutase / 0.654
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.654
4yry FADGlutamate synthase, beta subunit / 0.653
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.652
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.652
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.651
3pl8 FADPyranose 2-oxidase / 0.651
4ccq FADThioredoxin reductase / 0.651
4u8l FDAUDP-galactopyranose mutase / 0.651
1npx FADNADH peroxidase 1.11.1.1 0.650
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.650
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.650
4ccr FADThioredoxin reductase / 0.650