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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h1j 0YH Protein-tyrosine kinase 2-beta 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 1.270
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 1.030
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.820
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.798
3hv3 R49Mitogen-activated protein kinase 14 / 0.732
3hv6 R39Mitogen-activated protein kinase 14 / 0.715
3lff Z83Mitogen-activated protein kinase 14 / 0.709
3hv5 R24Mitogen-activated protein kinase 14 / 0.705
3lfe Z84Mitogen-activated protein kinase 14 / 0.702
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.696
3hv7 1AUMitogen-activated protein kinase 14 / 0.692
2yiw YIWMitogen-activated protein kinase 14 / 0.691
3lfb Z87Mitogen-activated protein kinase 14 / 0.689
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.682
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.681
3pg3 DG7Mitogen-activated protein kinase 14 / 0.679
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.678
3nnw EDDMitogen-activated protein kinase 14 / 0.676
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.668
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.668
2puu G2GMitogen-activated protein kinase 14 / 0.667
3gcu R48Mitogen-activated protein kinase 14 / 0.666
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.666
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.665
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.662
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.657
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.656
3hv4 L51Mitogen-activated protein kinase 14 / 0.655
2yis YISMitogen-activated protein kinase 14 / 0.654
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.651