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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4go2 TAP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.127
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.047
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.038
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.036
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.019
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.008
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.934
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.900
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.886
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.829
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.809
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.799
3b4w NADAldehyde dehydrogenase family protein / 0.799
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.793
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.792
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.788
4i8q NADPutative betaine aldehyde dehyrogenase / 0.787
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.786
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.785
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.784
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.783
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.778
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.771
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.765
4pz2 NADAldehyde dehydrogenase 2-6 / 0.763
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.761
4i8p NADAminoaldehyde dehydrogenase 1 / 0.754
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.750
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.749
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.749
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.748
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.746
2jg7 NADAntiquitin / 0.742
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.739
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.739
4pxl NADAldehyde dehydrogenase3 / 0.739
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.736
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.730
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.728
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.725
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.723
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.722
4i3v NADAldehyde dehydrogenase (NAD+) / 0.720
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.717
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.717
4h73 NDPAldehyde dehydrogenase / 0.716
4i3w NADAldehyde dehydrogenase (NAD+) / 0.715
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.713
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.710
5dib NADBetaine-aldehyde dehydrogenase / 0.710
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.709
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.707
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.706
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.705
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.704
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.704
3haz NADBifunctional protein PutA / 0.703
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.701
4i9b NADPutative betaine aldehyde dehyrogenase / 0.699
4pt0 NADAldehyde dehydrogenase / 0.697
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.695
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.694
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.694
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.693
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.693
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.691
4nmk NAPAldehyde dehydrogenase / 0.690
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.689
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.688
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.687
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.685
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.682
4f3x NADPutative aldehyde dehydrogenase / 0.682
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.680
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.679
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.678
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.678
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.668
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.668
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.667
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.660
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.657
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654
4nmj NAPAldehyde dehydrogenase / 0.651
4c3s NADAldehyde Dehydrogenase / 0.650