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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gnz NAP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.301
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.268
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.264
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.256
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.204
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.165
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.006
4i8p NADAminoaldehyde dehydrogenase 1 / 0.947
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.939
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.934
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.930
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.919
3b4w NADAldehyde dehydrogenase family protein / 0.914
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.909
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.905
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.904
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.902
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.900
4pz2 NADAldehyde dehydrogenase 2-6 / 0.894
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.872
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.871
4i8q NADPutative betaine aldehyde dehyrogenase / 0.871
2jg7 NADAntiquitin / 0.867
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.865
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.863
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.859
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.859
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.855
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.844
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.843
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.841
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.833
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.831
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.829
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.824
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.818
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.816
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.799
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.787
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.781
3haz NADBifunctional protein PutA / 0.776
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.771
4pxl NADAldehyde dehydrogenase3 / 0.768
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.765
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.764
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.745
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.743
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.741
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.736
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.736
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.735
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.733
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.729
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.725
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.725
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.723
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.720
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.719
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.719
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.718
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.717
4pt0 NADAldehyde dehydrogenase / 0.716
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.715
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.711
4i3w NADAldehyde dehydrogenase (NAD+) / 0.706
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.705
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.698
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.696
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.696
4i3v NADAldehyde dehydrogenase (NAD+) / 0.694
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.693
4f3x NADPutative aldehyde dehydrogenase / 0.693
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.689
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.683
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.681
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.680
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.679
4c3s NADAldehyde Dehydrogenase / 0.675
4l2o NADAldehyde dehydrogenase, dimeric NADP-preferring / 0.674
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.673
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.672
1bi9 NADRetinal dehydrogenase 2 / 0.671
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.671
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.658