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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gl4 NAI Alcohol dehydrogenase class-3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gl4 NAIAlcohol dehydrogenase class-3 / 0.940
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.844
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.842
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.840
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.838
4jji NADAlcohol dehydrogenase class-3 / 0.838
3uko NADAlcohol dehydrogenase class-3 / 0.826
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.821
4l0q NADAlcohol dehydrogenase class-3 / 0.820
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.757
1uxj NADMalate dehydrogenase / 0.757
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.756
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.755
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.749
1f8f NADBenzyl alcohol dehydrogenase / 0.744
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.739
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.735
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.733
1uxk NADMalate dehydrogenase / 0.732
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.731
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.728
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.720
4ejm NAPPutative zinc-binding dehydrogenase / 0.719
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.719
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
4cpd NADAlcohol dehydrogenase / 0.718
3wsw NADL-lactate dehydrogenase / 0.717
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.714
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.713
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.705
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.702
4oaq NDPR-specific carbonyl reductase / 0.700
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.699
2x0i NAIMalate dehydrogenase / 0.699
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.697
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.693
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.693
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.691
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.691
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.689
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.688
4j49 NAIUncharacterized protein / 0.688
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.687
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.686
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.686
2cdc NAPGlucose 1-dehydrogenase / 0.683
2vhx NADAlanine dehydrogenase 1.4.1.1 0.683
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.682
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.682
4j4b NAIUncharacterized protein / 0.681
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.680
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.679
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.679
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.679
1q7g NHOHomoserine dehydrogenase 1.1.1.3 0.678
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.674
4c4o NADSADH / 0.674
4j49 NADUncharacterized protein / 0.673
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.672
4j43 NADUncharacterized protein / 0.671
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.670
2cda NAPGlucose 1-dehydrogenase / 0.670
2xaa NADSecondary alcohol dehydrogenase / 0.669
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.668
3jv7 NADSecondary alcohol dehydrogenase / 0.668
3wle NAD(R)-specific carbonyl reductase / 0.667
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.666
4rqu NADAlcohol dehydrogenase class-P / 0.665
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.663
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.663
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.662
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.661
1llu NADAlcohol dehydrogenase / 0.661
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.661
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.660
2a92 NAIL-lactate dehydrogenase / 0.658
4i1i NADMalate dehydrogenase / 0.658
1x7d NADPutative ornithine cyclodeaminase / 0.657
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.657
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.657
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
4uun NAIL-lactate dehydrogenase / 0.656
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.654
2dbz NAPGlyoxylate reductase 1.1.1.26 0.654
2o4c NADErythronate-4-phosphate dehydrogenase / 0.654
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
4jk3 NADUncharacterized protein / 0.654
4xr9 NADCalS8 / 0.653
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.652
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.652
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.652
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.652
1bdm NAXMalate dehydrogenase / 0.651