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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gj3 0XP Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gj3 0XPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.961
4gii 0X6Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.856
4gj2 0XHNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.731
4gih 0X5Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.721
4gmy 0X5Tyrosine-protein kinase JAK2 / 0.678