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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gab FID Aldo-keto reductase family 1 member B10 1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gab FIDAldo-keto reductase family 1 member B10 1.1.1 0.844
2pdw FIDAldose reductase 1.1.1.21 0.778
4ga8 SBIAldo-keto reductase family 1 member B10 1.1.1 0.776
1ef3 FIDAldose reductase 1.1.1.21 0.757
2pd9 FIDAldose reductase 1.1.1.21 0.757
2pdy FIDAldose reductase 1.1.1.21 0.757
1pwm FIDAldose reductase 1.1.1.21 0.742
2agt FIDAldose reductase 1.1.1.21 0.741
3h4g FIDAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.731
2pdk SBIAldose reductase 1.1.1.21 0.716
1ah0 SBIAldose reductase 1.1.1.21 0.715