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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ga8 SBI Aldo-keto reductase family 1 member B10 1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ga8 SBIAldo-keto reductase family 1 member B10 1.1.1 0.808
4gab FIDAldo-keto reductase family 1 member B10 1.1.1 0.776
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3h4g FIDAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.732
1pwm FIDAldose reductase 1.1.1.21 0.721
2pdk SBIAldose reductase 1.1.1.21 0.720
2agt FIDAldose reductase 1.1.1.21 0.718
2pdw FIDAldose reductase 1.1.1.21 0.717
2pdy FIDAldose reductase 1.1.1.21 0.717
1ah0 SBIAldose reductase 1.1.1.21 0.698
2pd9 FIDAldose reductase 1.1.1.21 0.698
1ef3 FIDAldose reductase 1.1.1.21 0.672
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.658