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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g8z TOP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4g8z TOPDihydrofolate reductase 1.5.1.3 0.976
2w9g TOPDihydrofolate reductase 1.5.1.3 0.789
3frf XCFDihydrofolate reductase 1.5.1.3 0.745
3fra I2HDihydrofolate reductase 1.5.1.3 0.726
1dyr TOPDihydrofolate reductase 1.5.1.3 0.715
4m7v RARDihydrofolate reductase / 0.713
3fyv XCFDihydrofolate reductase 1.5.1.3 0.706
3fyw XCFDihydrofolate reductase 1.5.1.3 0.706
3fy9 XCFDihydrofolate reductase 1.5.1.3 0.690
4elh 53IDihydrofolate reductase / 0.684
2w9h TOPDihydrofolate reductase 1.5.1.3 0.681
4elf 35IDihydrofolate reductase / 0.667
1lud TRRDihydrofolate reductase 1.5.1.3 0.664
3srr Q20Dihydrofolate reductase 1.5.1.3 0.658
3fl9 TOPDihydrofolate reductase / 0.652
3sa1 6DRDihydrofolate reductase / 0.650