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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g3f 0WB Mitogen-activated protein kinase kinase kinase 14 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4g3f 0WBMitogen-activated protein kinase kinase kinase 14 2.7.11.25 1.119
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1di9 MSQMitogen-activated protein kinase 14 / 0.674
4xp1 LDPSodium-dependent dopamine transporter / 0.670
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
2ye9 2D4Heat shock protein HSP 90-alpha / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.659
2b1p AIZMitogen-activated protein kinase 10 2.7.11.24 0.658
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 0.657
3gxl QIGTGF-beta receptor type-1 2.7.11.30 0.652
2bre KJ2ATP-dependent molecular chaperone HSP82 / 0.650