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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g3e 0WC Mitogen-activated protein kinase kinase kinase 14 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4g3e 0WCMitogen-activated protein kinase kinase kinase 14 2.7.11.25 1.192
4idv 13VMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.796
4idt T28Mitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.742
3e8e G98cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660