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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g2f C07 Ephrin type-A receptor 3 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4g2f C07Ephrin type-A receptor 3 2.7.10.1 1.030
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 0.751
4gk2 L66Ephrin type-A receptor 3 2.7.10.1 0.735
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.725
2xvd AS6Ephrin type-B receptor 4 2.7.10.1 0.712
4gk3 L87Ephrin type-A receptor 3 2.7.10.1 0.706
2vx0 7X7Ephrin type-B receptor 4 2.7.10.1 0.700
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.699
4gk4 L90Ephrin type-A receptor 3 2.7.10.1 0.692
2vx1 7X8Ephrin type-B receptor 4 2.7.10.1 0.690
2xyu Q9GEphrin type-A receptor 4 2.7.10.1 0.686
2vwx 7X4Ephrin type-B receptor 4 2.7.10.1 0.674
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.669
2vwy 7X5Ephrin type-B receptor 4 2.7.10.1 0.665
3gcv SS6Mitogen-activated protein kinase 14 / 0.662
1w83 L11Mitogen-activated protein kinase 14 / 0.661
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.658
4aa5 NQBMitogen-activated protein kinase 14 / 0.657
4aac AAVMitogen-activated protein kinase 14 / 0.653