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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fux E75 Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fux E75Mitogen-activated protein kinase 1 2.7.11.24 0.907
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.710
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.687
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.680
3erk SB4Mitogen-activated protein kinase 1 2.7.11.24 0.672
4e5f 0N7Polymerase acidic protein / 0.660
4loo SB4Mitogen-activated protein kinase 14 / 0.660