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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftr 5HK Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 1.028
4ft0 HK9Serine/threonine-protein kinase Chk1 2.7.11.1 1.002
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.961
4ftu 7HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.845
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.836
4fsy HK7Serine/threonine-protein kinase Chk1 2.7.11.1 0.830
4fsw HK6Serine/threonine-protein kinase Chk1 2.7.11.1 0.817
4fsz HK8Serine/threonine-protein kinase Chk1 2.7.11.1 0.753
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.730
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.685
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.681
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.673
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.665
4e20 0MYNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.661
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.658
4jbq VX6Aurora kinase A 2.7.11.1 0.651
1y6b AAXVascular endothelial growth factor receptor 2 2.7.10.1 0.650
4g17 0VNCasein kinase I isoform gamma-3 2.7.11.1 0.650