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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftm 1HK Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ftm 1HKSerine/threonine-protein kinase Chk1 2.7.11.1 1.077
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.922
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.801
3t9i 3T9Serine/threonine-protein kinase pim-1 2.7.11.1 0.737
2ayp 43ASerine/threonine-protein kinase Chk1 2.7.11.1 0.709
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.701
5auw QUEDeath-associated protein kinase 1 2.7.11.1 0.699
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.669
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.663
2e9n 76ASerine/threonine-protein kinase Chk1 2.7.11.1 0.658
2zm4 KSMTyrosine-protein kinase Lck 2.7.10.2 0.658
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.650